Prevalence of diabetes mellitus in 6050 hypopituitary patients with adult-onset GH deficiency before GH replacement

A KIMS analysis

Roger Abs, Anders F. Mattsson, Maria Thunander, Johan Verhelst, M. Góth, Patrick Wilton, Maria Kołtowska-Häggström, Anton Luger

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: GH deficiency (GHD) in adults is characterized by a tendency toward obesity and an adverse body composition with visceral fat deposit and may thus predispose to the development of type 2 diabetes mellitus. The aim of this study was to assess the observed prevalence proportion (PP) and observed PP over expected PP ratio (standardized prevalence proportion ratio, SPR) of diabetes according to International Diabetes Federation criteria in a large cohort of GH-untreated adult-onset GHD patients. Design and methods: Associations between baseline variables and diabetes prevalence in 6050 GHD patients from KIMS (Pfizer International Metabolic Database) were studied and robust Poisson-regression analyses were performed. Comparisons between baseline status and HbA1c categories in the nondiabetic patients were done with covariance analysis. P values

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalEuropean Journal of Endocrinology
Volume168
Issue number3
DOIs
Publication statusPublished - Mar 2013

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Diabetes Mellitus
Intra-Abdominal Fat
Body Composition
Type 2 Diabetes Mellitus
Obesity
Regression Analysis
Databases

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Prevalence of diabetes mellitus in 6050 hypopituitary patients with adult-onset GH deficiency before GH replacement : A KIMS analysis. / Abs, Roger; Mattsson, Anders F.; Thunander, Maria; Verhelst, Johan; Góth, M.; Wilton, Patrick; Kołtowska-Häggström, Maria; Luger, Anton.

In: European Journal of Endocrinology, Vol. 168, No. 3, 03.2013, p. 297-305.

Research output: Contribution to journalArticle

Abs, Roger ; Mattsson, Anders F. ; Thunander, Maria ; Verhelst, Johan ; Góth, M. ; Wilton, Patrick ; Kołtowska-Häggström, Maria ; Luger, Anton. / Prevalence of diabetes mellitus in 6050 hypopituitary patients with adult-onset GH deficiency before GH replacement : A KIMS analysis. In: European Journal of Endocrinology. 2013 ; Vol. 168, No. 3. pp. 297-305.
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