Prevalence of cognitive impairment among Hungarian patients with relapsing-remitting multiple sclerosis and clinically isolated syndrome

Dániel Sandi, Tamás Biernacki, Dóra Szekeres, Judit Füvesi, Zsigmond Tamás Kincses, C. Rózsa, Klotild Mátyás, Krisztián Kása, Judit Matolcsi, Dóra Zboznovits, Zita Burány, Éva Langane, L. Vécsei, K. Bencsik

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Cognitive impairment (CI) is a frequent symptom of multiple sclerosis (MS); its prevalence is reported to be 43–70%. It is one of the most important determinants of MS patients’ quality of life, as it is one of the main factors for MS patients becoming unemployed. Aim We aimed to determine the prevalence of CI among the relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS) patients in Hungary, to evaluate the predicting factors of CI and to assess the differences between sexes and patients with different educational levels. Patients and methods Five-hundred and fifty-three CIS and RRMS patients were enrolled to our study from three Hungarian MS centers. Age at screening, age at disease onset, disease duration, EDSS score, sex and educational levels were analyzed as socio-demographic factors. The BICAMS battery was used to assess their cognitive state, the BDI-II battery to assess depression. For statistical analysis, we utilized logistical regression, and used Fisher exact tests, chi-square tests and one-way ANOVA. Results The mean age of our patients was 44.93 ± 11.69 years, mean age at disease onset was 31.95 ± 10.01 years, the mean disease duration was 13.05 ± 8.05 years and the median EDSS score 2.0 (Range: 6.5, IQR:2.0) points. Three-hundred and sixteen (57.1%) patients had CI. Sex, educational level and EDSS score proved to be significant predictors of CI (OR: 2.71, p < 0.001; OR: 1.94, p = 0.023; OR: 0.47, p = 0.003 respectively). CI was significantly (p < 0.001) more frequent among men (70.1%) than women (52.0%). We found, that educational level and EDSS score were only a significant predicting factor among women. Thus, the prevalence of CI among women with college or university degree was significantly (p < 0.001) less common (39.4%) than women with 12–15 years of education (57.4%) and women without a high school degree (66.7%). Also, we found that among women with higher EDSS score than 2 points, the prevalence of CI is 69.9% as compared to women with EDSS score between 0 and 2 points, where the prevalence is 42.8% (p < 0.001). No such differences were observed among man. Discussion Our prevalence data is similar to those reported in the literature (43–70%), and almost identical to the one assessment using the BICAMS battery. We found that men are more vulnerable to CI than women in MS, as was reported recently. We are the first to report however, that higher educational level and lower EDSS scores are only associated with better cognitive performance in women.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalMultiple Sclerosis and Related Disorders
Volume17
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Multiple Sclerosis
Age of Onset
Cognitive Dysfunction
Hungary
Chi-Square Distribution
Sex Characteristics
Analysis of Variance
Quality of Life
Demography
Depression
Education

Keywords

  • BICAMS
  • Cognitive impairment
  • Hungary
  • Multiple sclerosis
  • Prevalence

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Prevalence of cognitive impairment among Hungarian patients with relapsing-remitting multiple sclerosis and clinically isolated syndrome. / Sandi, Dániel; Biernacki, Tamás; Szekeres, Dóra; Füvesi, Judit; Kincses, Zsigmond Tamás; Rózsa, C.; Mátyás, Klotild; Kása, Krisztián; Matolcsi, Judit; Zboznovits, Dóra; Burány, Zita; Langane, Éva; Vécsei, L.; Bencsik, K.

In: Multiple Sclerosis and Related Disorders, Vol. 17, 01.10.2017, p. 57-62.

Research output: Contribution to journalArticle

Sandi, Dániel ; Biernacki, Tamás ; Szekeres, Dóra ; Füvesi, Judit ; Kincses, Zsigmond Tamás ; Rózsa, C. ; Mátyás, Klotild ; Kása, Krisztián ; Matolcsi, Judit ; Zboznovits, Dóra ; Burány, Zita ; Langane, Éva ; Vécsei, L. ; Bencsik, K. / Prevalence of cognitive impairment among Hungarian patients with relapsing-remitting multiple sclerosis and clinically isolated syndrome. In: Multiple Sclerosis and Related Disorders. 2017 ; Vol. 17. pp. 57-62.
@article{0db6b1d6c55d4396b90abe56415c835c,
title = "Prevalence of cognitive impairment among Hungarian patients with relapsing-remitting multiple sclerosis and clinically isolated syndrome",
abstract = "Background Cognitive impairment (CI) is a frequent symptom of multiple sclerosis (MS); its prevalence is reported to be 43–70{\%}. It is one of the most important determinants of MS patients’ quality of life, as it is one of the main factors for MS patients becoming unemployed. Aim We aimed to determine the prevalence of CI among the relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS) patients in Hungary, to evaluate the predicting factors of CI and to assess the differences between sexes and patients with different educational levels. Patients and methods Five-hundred and fifty-three CIS and RRMS patients were enrolled to our study from three Hungarian MS centers. Age at screening, age at disease onset, disease duration, EDSS score, sex and educational levels were analyzed as socio-demographic factors. The BICAMS battery was used to assess their cognitive state, the BDI-II battery to assess depression. For statistical analysis, we utilized logistical regression, and used Fisher exact tests, chi-square tests and one-way ANOVA. Results The mean age of our patients was 44.93 ± 11.69 years, mean age at disease onset was 31.95 ± 10.01 years, the mean disease duration was 13.05 ± 8.05 years and the median EDSS score 2.0 (Range: 6.5, IQR:2.0) points. Three-hundred and sixteen (57.1{\%}) patients had CI. Sex, educational level and EDSS score proved to be significant predictors of CI (OR: 2.71, p < 0.001; OR: 1.94, p = 0.023; OR: 0.47, p = 0.003 respectively). CI was significantly (p < 0.001) more frequent among men (70.1{\%}) than women (52.0{\%}). We found, that educational level and EDSS score were only a significant predicting factor among women. Thus, the prevalence of CI among women with college or university degree was significantly (p < 0.001) less common (39.4{\%}) than women with 12–15 years of education (57.4{\%}) and women without a high school degree (66.7{\%}). Also, we found that among women with higher EDSS score than 2 points, the prevalence of CI is 69.9{\%} as compared to women with EDSS score between 0 and 2 points, where the prevalence is 42.8{\%} (p < 0.001). No such differences were observed among man. Discussion Our prevalence data is similar to those reported in the literature (43–70{\%}), and almost identical to the one assessment using the BICAMS battery. We found that men are more vulnerable to CI than women in MS, as was reported recently. We are the first to report however, that higher educational level and lower EDSS scores are only associated with better cognitive performance in women.",
keywords = "BICAMS, Cognitive impairment, Hungary, Multiple sclerosis, Prevalence",
author = "D{\'a}niel Sandi and Tam{\'a}s Biernacki and D{\'o}ra Szekeres and Judit F{\"u}vesi and Kincses, {Zsigmond Tam{\'a}s} and C. R{\'o}zsa and Klotild M{\'a}ty{\'a}s and Kriszti{\'a}n K{\'a}sa and Judit Matolcsi and D{\'o}ra Zboznovits and Zita Bur{\'a}ny and {\'E}va Langane and L. V{\'e}csei and K. Bencsik",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.msard.2017.06.017",
language = "English",
volume = "17",
pages = "57--62",
journal = "Multiple Sclerosis and Related Disorders",
issn = "2211-0348",
publisher = "Elsevier",

}

TY - JOUR

T1 - Prevalence of cognitive impairment among Hungarian patients with relapsing-remitting multiple sclerosis and clinically isolated syndrome

AU - Sandi, Dániel

AU - Biernacki, Tamás

AU - Szekeres, Dóra

AU - Füvesi, Judit

AU - Kincses, Zsigmond Tamás

AU - Rózsa, C.

AU - Mátyás, Klotild

AU - Kása, Krisztián

AU - Matolcsi, Judit

AU - Zboznovits, Dóra

AU - Burány, Zita

AU - Langane, Éva

AU - Vécsei, L.

AU - Bencsik, K.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background Cognitive impairment (CI) is a frequent symptom of multiple sclerosis (MS); its prevalence is reported to be 43–70%. It is one of the most important determinants of MS patients’ quality of life, as it is one of the main factors for MS patients becoming unemployed. Aim We aimed to determine the prevalence of CI among the relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS) patients in Hungary, to evaluate the predicting factors of CI and to assess the differences between sexes and patients with different educational levels. Patients and methods Five-hundred and fifty-three CIS and RRMS patients were enrolled to our study from three Hungarian MS centers. Age at screening, age at disease onset, disease duration, EDSS score, sex and educational levels were analyzed as socio-demographic factors. The BICAMS battery was used to assess their cognitive state, the BDI-II battery to assess depression. For statistical analysis, we utilized logistical regression, and used Fisher exact tests, chi-square tests and one-way ANOVA. Results The mean age of our patients was 44.93 ± 11.69 years, mean age at disease onset was 31.95 ± 10.01 years, the mean disease duration was 13.05 ± 8.05 years and the median EDSS score 2.0 (Range: 6.5, IQR:2.0) points. Three-hundred and sixteen (57.1%) patients had CI. Sex, educational level and EDSS score proved to be significant predictors of CI (OR: 2.71, p < 0.001; OR: 1.94, p = 0.023; OR: 0.47, p = 0.003 respectively). CI was significantly (p < 0.001) more frequent among men (70.1%) than women (52.0%). We found, that educational level and EDSS score were only a significant predicting factor among women. Thus, the prevalence of CI among women with college or university degree was significantly (p < 0.001) less common (39.4%) than women with 12–15 years of education (57.4%) and women without a high school degree (66.7%). Also, we found that among women with higher EDSS score than 2 points, the prevalence of CI is 69.9% as compared to women with EDSS score between 0 and 2 points, where the prevalence is 42.8% (p < 0.001). No such differences were observed among man. Discussion Our prevalence data is similar to those reported in the literature (43–70%), and almost identical to the one assessment using the BICAMS battery. We found that men are more vulnerable to CI than women in MS, as was reported recently. We are the first to report however, that higher educational level and lower EDSS scores are only associated with better cognitive performance in women.

AB - Background Cognitive impairment (CI) is a frequent symptom of multiple sclerosis (MS); its prevalence is reported to be 43–70%. It is one of the most important determinants of MS patients’ quality of life, as it is one of the main factors for MS patients becoming unemployed. Aim We aimed to determine the prevalence of CI among the relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS) patients in Hungary, to evaluate the predicting factors of CI and to assess the differences between sexes and patients with different educational levels. Patients and methods Five-hundred and fifty-three CIS and RRMS patients were enrolled to our study from three Hungarian MS centers. Age at screening, age at disease onset, disease duration, EDSS score, sex and educational levels were analyzed as socio-demographic factors. The BICAMS battery was used to assess their cognitive state, the BDI-II battery to assess depression. For statistical analysis, we utilized logistical regression, and used Fisher exact tests, chi-square tests and one-way ANOVA. Results The mean age of our patients was 44.93 ± 11.69 years, mean age at disease onset was 31.95 ± 10.01 years, the mean disease duration was 13.05 ± 8.05 years and the median EDSS score 2.0 (Range: 6.5, IQR:2.0) points. Three-hundred and sixteen (57.1%) patients had CI. Sex, educational level and EDSS score proved to be significant predictors of CI (OR: 2.71, p < 0.001; OR: 1.94, p = 0.023; OR: 0.47, p = 0.003 respectively). CI was significantly (p < 0.001) more frequent among men (70.1%) than women (52.0%). We found, that educational level and EDSS score were only a significant predicting factor among women. Thus, the prevalence of CI among women with college or university degree was significantly (p < 0.001) less common (39.4%) than women with 12–15 years of education (57.4%) and women without a high school degree (66.7%). Also, we found that among women with higher EDSS score than 2 points, the prevalence of CI is 69.9% as compared to women with EDSS score between 0 and 2 points, where the prevalence is 42.8% (p < 0.001). No such differences were observed among man. Discussion Our prevalence data is similar to those reported in the literature (43–70%), and almost identical to the one assessment using the BICAMS battery. We found that men are more vulnerable to CI than women in MS, as was reported recently. We are the first to report however, that higher educational level and lower EDSS scores are only associated with better cognitive performance in women.

KW - BICAMS

KW - Cognitive impairment

KW - Hungary

KW - Multiple sclerosis

KW - Prevalence

UR - http://www.scopus.com/inward/record.url?scp=85021771935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021771935&partnerID=8YFLogxK

U2 - 10.1016/j.msard.2017.06.017

DO - 10.1016/j.msard.2017.06.017

M3 - Article

VL - 17

SP - 57

EP - 62

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

ER -