Prevalence of antiphospholipid and antinuclear antibodies in children with epilepsy

Tamás Constantin, Tamás Kálovics, Andrea Ponyi, Eszter Nagy, Krisztina Sallai, Léna Szabó, Miklós Garami, Judit Müller, Péter Gergely, Katalin Dankó, György Fekete, Rozália Kálmánchey

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Background: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent venous thrombosis or arterial occlusive events and fetal losses associated with elevated levels of antiphospholipid antibodies (aPLs). Material/Methods: The presence of antinuclear, anti-β2-glycoprotein I, and anticardiolipin antibodies were investigated in 60 consecutive children with epilepsy who were followed up in a single Hungarian center. Results: Almost 50% (28/60) of the patients were ANA positive. Twelve (20%) patients had moderate titer (1:160) of ANA. Anti-C1q antibody was positive in 4 cases, all of them symptom free considering renal manifestation of lupus. Interestingly, only 1 child had aCL antibody, while 6/43 patients were LAC positive. Five were also ANA positive among the LAC positive patients (4 children with moderate titer). Anti-β2GPI antibody positivity was not detected in this cohort of patients. Conclusions: The clinical relevance of aPL tests in childhood are difficult to explain. In the present study, obviously lower total prevalence of aPLs (aCL and anti-β2GPI) was observed in children with epilepsy than in previously reported investigations (20-30%). The higher amount of LAC-positive patients indicates that coagulation studies (LAC) should be included in the neuroimmunological assessment of suspected APS patients with epileptic disorders. The difference between the results of serological and LAC studies could be explained by the possible positivity of other, uninvestigated antibodies. The wide spectrum of detected immunological alterations highlight the importance of the participation of pediatric rheumatologists in the management of patients with idiopathic epilepsy or with secondary induced autoimmune disease due to antiepileptic medications.

Original languageEnglish
Pages (from-to)CR164-CR169
JournalMedical Science Monitor
Issue number4
Publication statusPublished - Jun 1 2009


  • Antiphospholipid antibodies
  • Epilepsy
  • Lupus anticoagulant

ASJC Scopus subject areas

  • Medicine(all)

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