Prevalence of anti-beta-2 microglobulin autoantibodies in sera of rheumatoid arthritis patients with extra-articular manifestations

A. Falus, K. Meretey, S. Bozsoky

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Abstract

The frequency and concentration of specific factors binding β2 microglobulin were investigated in sera and synovial fluids of patients and in sera of normal controls. High anti-β2m activity was detected in the sera of adult RA patients, particularly in those of with extra-articular disease. Similarly, anti-β2m was present in the synovial fluids of RA but not of osteoarthrosis patients. Both the binding of anti-β2m activity to the Sepharose staphylococcal protein A and its elution position in the second 'IgG' peak after Sephadex G-200 gel filtration suggest the antibody nature of the activity. The possibility of differences not only in titre but also in the specificity of heterologous and homologous anti-β2m antibodies are discussed.

Original languageEnglish
Pages (from-to)409-413
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume40
Issue number4
DOIs
Publication statusPublished - Jan 1 1981

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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