Prevalence of Anal Human Papillomavirus Infection in Hungarian Men Who Have Sex with Men

Eszter Szabó, Csaba Kósa, Edit Babarczi, Mihály Sulyok, E. Újhelyi, D. Bánhegyi, István Vályi-Nagy

Research output: Contribution to journalArticle

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Abstract

Anal cancer is one of the leading causes of death in non-AIDS defining cancers. Most of these cancers are associated with high risk HPV infection. So far, the prevalence and the significance of anal HPV infection have not been studied in the Hungarian MSM population. The main objective of our study was to determine the prevalence and associated risk factors of HPV-infection in the Hungarian MSM community, particularly in HIV-infected MSM. Out of 109 examinations 92 samples (80 HIV-infected and 12 HIV-negative MSM) were evaluated for both cytological abnormalities and HPV genotyping PCR. Using a questionnaire all enrolled individuals were interviewed about their sexual behavior, socioeconomic factors, drug use and other known or suspected risk factors. In the HIV-infected cohort 97.5% of the examined individuals were positive for any HPV type. In this group we detected high risk (HR) HPV in 88.8%, low risk (LR) HPV in 75.0% and probably high risk (PHR) HPV in 47.5% and multiple HPV infection was absolutely common (82.5%). In the HIV-negative MSM group the incidence of HPV-infection was 58.3%. The respective rate of HR-HPV, LR-HPV and PHR-HPV genotypes were 33.3%, 58.4%, and 16.7%. In the HIV-negative group both HPV infection frequency and the prevalence of the pertinent genotypes were much lower. The Hungarian MSM population is severely infected with HPV and HR-HPV. High-risk sexual behaviors are strong predictors for acquiring HR-HPV co-infections. Our results underline the necessity of anal cancer screening and the introduction of the vaccination program in the high-risk population.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalPathology and Oncology Research
DOIs
Publication statusAccepted/In press - Aug 24 2017

Fingerprint

Papillomavirus Infections
HIV
Infection
Anus Neoplasms
Sexual Behavior
Genotype
Population
Risk-Taking
Coinfection
Early Detection of Cancer
Cause of Death
Neoplasms
Vaccination
Polymerase Chain Reaction

Keywords

  • Anal cancer screening
  • HIV-infected MSM
  • HPV
  • HPV genotype
  • MSM
  • Risk factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Prevalence of Anal Human Papillomavirus Infection in Hungarian Men Who Have Sex with Men. / Szabó, Eszter; Kósa, Csaba; Babarczi, Edit; Sulyok, Mihály; Újhelyi, E.; Bánhegyi, D.; Vályi-Nagy, István.

In: Pathology and Oncology Research, 24.08.2017, p. 1-7.

Research output: Contribution to journalArticle

Szabó, Eszter ; Kósa, Csaba ; Babarczi, Edit ; Sulyok, Mihály ; Újhelyi, E. ; Bánhegyi, D. ; Vályi-Nagy, István. / Prevalence of Anal Human Papillomavirus Infection in Hungarian Men Who Have Sex with Men. In: Pathology and Oncology Research. 2017 ; pp. 1-7.
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