Prevalence, course and risk factors of diabetic nephropathy in type-2 diabetes mellitus

M. Molnar, I. Wittmann, J. Nagy

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23 Citations (Scopus)

Abstract

Contrary to the well-known features of diabetic nephropathy (DNP) in type-1 diabetic patients (pts), the prevalence, course and risk factors of DNP in in type-2 diabetic pts are not clear. The aim of the present study was to assess the prevalence of microalbuminuria (MA) and macroalbuminuria (MAA), their relationship with other diabetic complications and with some known cardiovascular risk factors in 200 in type-2 diabetic pts (100 females and 100 males). 68 pts (33%) were normalbuminuric (NA), 55 (27.5%) had MA and 77 (38.5%) had MAA. There was no significant difference among these three groups in age, BMI or the time actually elapsed since the diabetes and hypertension were diagnosed. BMI was high in each group (28.8±5.29, 28.0±5.2 and 29.8±4.6 kg/m2 mean±SD). 65% of pts with NA, 77% of those with MA and 81% of pts with MAA had hypertension. MAA pts were more frequently smokers and former smokers, than MA and NA pts (56% vs 32% and 22%). Average GRF values (ml/min/1.73 m2) were 71.9±26.8 in NA pts, 82.3±36.8 in MA pts and 56.3±32 in MAA pts. There was no significant correlation between the urinary albumin excretion (UAE) and glycemic control, serum (se) cholesterol and se HDL cholesterol. At the same time UAE showed a significant positive correlation with se trigliceride (P

Original languageEnglish
Pages (from-to)929-936
Number of pages8
JournalMedical Science Monitor
Volume6
Issue number5
Publication statusPublished - 2000

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Diabetic Nephropathies
Type 2 Diabetes Mellitus
Albumins
Serum
Hypertension
Diabetes Complications
HDL Cholesterol
Age Groups
Cholesterol

Keywords

  • Diabetic nephropathy
  • End stage renal disease
  • Macroalbuminuria
  • Microalbuminuria
  • Type-2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevalence, course and risk factors of diabetic nephropathy in type-2 diabetes mellitus. / Molnar, M.; Wittmann, I.; Nagy, J.

In: Medical Science Monitor, Vol. 6, No. 5, 2000, p. 929-936.

Research output: Contribution to journalArticle

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