Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012

Petra A. Golovics, L. Lakatos, Michael D. Mandel, Barbara D. Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Istvan Szita, Lajos S. Kiss, T. Pandúr, P. Lakatos

Research output: Contribution to journalArticle

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Abstract

AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province. METHODS: Data of 331 incident Crohn's disease (CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed. RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%, 53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures (37%), surgery or disease activity (27% and 21%). Non-inflammatory disease behavior at diagnosis (HR = 1.32, P = 0.001) and perianal disease (HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change (HR = 2.38, P = 0.002) and need for steroids (HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses. Early CD-related hospitalization (within the year of diagnosis) was independently associated with need for immunosuppressives (OR = 2.08, P = 0.001) and need for surgeries (OR = 7.25, P <0.001) during the disease course. CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization.

Original languageEnglish
Pages (from-to)7272-7280
Number of pages9
JournalWorld Journal of Gastroenterology
Volume21
Issue number23
DOIs
Publication statusPublished - Jun 21 2015

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Crohn Disease
Hospitalization
Population
Kaplan-Meier Estimate
Immunosuppressive Agents
Inpatients
Outpatients
Multivariate Analysis
Steroids

Keywords

  • Biological therapy
  • Crohn's disease
  • Hospitalization
  • Population-based
  • Predictor
  • Recurrence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012. / Golovics, Petra A.; Lakatos, L.; Mandel, Michael D.; Lovasz, Barbara D.; Vegh, Zsuzsanna; Kurti, Zsuzsanna; Szita, Istvan; Kiss, Lajos S.; Pandúr, T.; Lakatos, P.

In: World Journal of Gastroenterology, Vol. 21, No. 23, 21.06.2015, p. 7272-7280.

Research output: Contribution to journalArticle

Golovics, Petra A. ; Lakatos, L. ; Mandel, Michael D. ; Lovasz, Barbara D. ; Vegh, Zsuzsanna ; Kurti, Zsuzsanna ; Szita, Istvan ; Kiss, Lajos S. ; Pandúr, T. ; Lakatos, P. / Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012. In: World Journal of Gastroenterology. 2015 ; Vol. 21, No. 23. pp. 7272-7280.
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abstract = "AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province. METHODS: Data of 331 incident Crohn's disease (CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed. RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3{\%}, 45.5{\%}, 53.7{\%} and 13.6{\%}, 23.9{\%}, 29.8{\%}, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures (37{\%}), surgery or disease activity (27{\%} and 21{\%}). Non-inflammatory disease behavior at diagnosis (HR = 1.32, P = 0.001) and perianal disease (HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change (HR = 2.38, P = 0.002) and need for steroids (HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses. Early CD-related hospitalization (within the year of diagnosis) was independently associated with need for immunosuppressives (OR = 2.08, P = 0.001) and need for surgeries (OR = 7.25, P <0.001) during the disease course. CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization.",
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T1 - Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012

AU - Golovics, Petra A.

AU - Lakatos, L.

AU - Mandel, Michael D.

AU - Lovasz, Barbara D.

AU - Vegh, Zsuzsanna

AU - Kurti, Zsuzsanna

AU - Szita, Istvan

AU - Kiss, Lajos S.

AU - Pandúr, T.

AU - Lakatos, P.

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N2 - AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province. METHODS: Data of 331 incident Crohn's disease (CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed. RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%, 53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures (37%), surgery or disease activity (27% and 21%). Non-inflammatory disease behavior at diagnosis (HR = 1.32, P = 0.001) and perianal disease (HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change (HR = 2.38, P = 0.002) and need for steroids (HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses. Early CD-related hospitalization (within the year of diagnosis) was independently associated with need for immunosuppressives (OR = 2.08, P = 0.001) and need for surgeries (OR = 7.25, P <0.001) during the disease course. CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization.

AB - AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province. METHODS: Data of 331 incident Crohn's disease (CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed. RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%, 53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures (37%), surgery or disease activity (27% and 21%). Non-inflammatory disease behavior at diagnosis (HR = 1.32, P = 0.001) and perianal disease (HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change (HR = 2.38, P = 0.002) and need for steroids (HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses. Early CD-related hospitalization (within the year of diagnosis) was independently associated with need for immunosuppressives (OR = 2.08, P = 0.001) and need for surgeries (OR = 7.25, P <0.001) during the disease course. CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization.

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KW - Crohn's disease

KW - Hospitalization

KW - Population-based

KW - Predictor

KW - Recurrence

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