Prevalence and characterization of nim genes of Bacteroides spp. isolated in Hungary

E. Urbán, J. Sóki, Jon S. Brazier, E. Nagy, Brian I. Duerden

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Members of the Bacteroides spp. are the anaerobic pathogens most commonly isolated from human clinical material. Metronidazole has been the drug of choice for the prevention and treatment of Bacteroides and other such anaerobic infections for nearly 40 years. Although the emergence of metronidazole-resistance in Bacteroides spp. was reported recently, the published rate remains low, at 2 μg/mL, and two were positive fornim genes with metronidazole MICs of 4 and 12 μg/mL. The nim genes were determined to be nim A and nim B, and proved to be activated by upstream copies of the IS1186 element. The nim A gene was localized in a pIP417-like plasmid, and the nim B gene on the chromosome.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalAnaerobe
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 2002

Fingerprint

Bacteroides
Hungary
Metronidazole
Genes
Plasmids
Chromosomes
Infection
Pharmaceutical Preparations

Keywords

  • Bacteroides fragilis
  • IS1186
  • Metronidazole
  • nim genes
  • pIP417

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Prevalence and characterization of nim genes of Bacteroides spp. isolated in Hungary. / Urbán, E.; Sóki, J.; Brazier, Jon S.; Nagy, E.; Duerden, Brian I.

In: Anaerobe, Vol. 8, No. 4, 08.2002, p. 175-179.

Research output: Contribution to journalArticle

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