Pretreatment with GABA and modulatory ligands enhances GABA receptor binding

Gábor Maksay, Maharaj K. Ticku

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

GABA pretreatment at 37 ° C but not at 4 ° C enhanced subsequent [3H]GABA binding in a concentration-dependent manner (EC50 = 440 nM) by increasing the number of high and low affinity sites. The effect mediated by GABAA receptors was attenuated by bicuculline methiodide and picrotoxinin and potentiated by pentobarbial, flurazepam and Triton X-100. These results can be interpreted by the facilitated removal of endogenous substances and/or by a temperature-restricted conversion of the GABA receptor populations.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalEuropean Journal of Pharmacology
Volume104
Issue number1-2
DOIs
Publication statusPublished - Sep 3 1984

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Keywords

  • Endogenous substances
  • Enhancement of binding
  • GABA receptor complex
  • Ligand pretreatment
  • Receptor convertibility

ASJC Scopus subject areas

  • Pharmacology

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