Presynaptic release of ATP from superior cervical ganglion of rats modulated by various receptors

Shang Dong Liang, E. Sylvester Vizi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

AIM: To determine whether adenosine 5'-triphosphate (ATP) is released from the superior cervical ganglion (SCG) of rats and whether the release is regulated by presynaptic mechanism. METHODS: Using the luciferin-luciferase technique. RESULTS: Electric stimulation evoked the release of ATP from the rat SCG. Adenosine (100 μmol·L-1), P1 (A1) purinoceptor agonist N6- cyclopentyladenosine (0.1 μmol·L-1), the muscarinic agonist oxotremorine (1 μmol·L-1), and 5-hydroxytryptamine (100 μmolΛ-1) decreased the evoked release of ATP from the rat SCG. On the contrary, P1 (A1) purinoceptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (10 nmol·L-1), P2 purinoceptor antagonist pyridoxal-5-phosphate-6-azophenyl-2',4'- disulphonic acid (10 μmol·L-1), muscarinic antagonist atropine (1 μmol·L-1), α2 adrenoceptor antagonist yohimbine (3 μmol·L-1), D2 dopamine receptor antagonist sulpiride (20 μmol·L-1), and histamine (100 μmol·L-1) increased the evoked release of ATP from the rat SCG. CONCLUSION: ATP is released from the rat SCG and the release of ATP can be presynaptically modulated by P1 (A1), P2, muscarinic, α2 adrenergic, D2, 5-HT, and H1 receptor agonists and antagonists.

Original languageEnglish
Pages (from-to)589-591
Number of pages3
JournalActa Pharmacologica Sinica
Volume20
Issue number7
Publication statusPublished - Aug 2 1999

Keywords

  • Adenosine triphosphate
  • Atropine
  • Histamine
  • Oxotremorine
  • Serotonin
  • Sulpiride
  • Superior cervical ganglion
  • Yohimbine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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