Presynaptic modification of synaptic transmission at identified Aplysia central synapses, induced by changes in protein kinase C activity

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Abstract

The effect of altered protein kinase C (PKC) activity level on the synaptic transmission in the central ganglia of Aplysia californica was studied. EPSPs or EPSCs evoked in the postsynaptic neuron by presynaptic nerve stimulation were recorded while the ganglion was in vitro treated with PKC activators (phorbol diacetate and SC-10) or PKC blockers (H-7, sphingosine, Cremophor-EL). It was found that the postsynaptic reaction was enhanced by increased and reduced by decreased PKC activity and that this modulatory influence of PKC was presynaptic.

Original languageEnglish
Pages (from-to)203-216
Number of pages14
JournalNeurobiology
Volume4
Issue number3
Publication statusPublished - 1996

Fingerprint

Aplysia
Synaptic Transmission
Synapses
Protein Kinase C
Ganglia
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Sphingosine
Excitatory Postsynaptic Potentials
Neurons

Keywords

  • Aplysia
  • Postsynaptic potential and current
  • Protein kinase C
  • Protein kinase C activators and blockers

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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AB - The effect of altered protein kinase C (PKC) activity level on the synaptic transmission in the central ganglia of Aplysia californica was studied. EPSPs or EPSCs evoked in the postsynaptic neuron by presynaptic nerve stimulation were recorded while the ganglion was in vitro treated with PKC activators (phorbol diacetate and SC-10) or PKC blockers (H-7, sphingosine, Cremophor-EL). It was found that the postsynaptic reaction was enhanced by increased and reduced by decreased PKC activity and that this modulatory influence of PKC was presynaptic.

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