Presynaptic inhibitory effect of TNF-α on the release of noradrenaline in isolated median eminence

I. J. Elenkov, K. Kovács, E. Duda, E. Stark, E. Vízi

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Abstract

The effect of tumor necrosis factor-α (TNF-α) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system. Median eminence, loaded with [3H]noradrenaline, was superfused with Krebs solution and stimulated electrically (2 Hz, 120 shocks). The effect of TNF-α was studied on the S2 S1 ration. It was found that stimulation-evoked relesed of NA from noradrenergic axon terminals in the isolated rat ME was inhibited by TNF-α and this effect was concentration-dependent. In contrast, TNF-α had no effect on the release of [3H]NA from the spleen. Since NA released in the ME might be involved in the modulation of corticotropin-releasing factor (CRF) production, it is suggested that TNF-α, through presynaptic modulation of NA release from noradrenergic nerve terminals in the ME, might regulate CRF and other neurohormone release in this hypothalamic structure.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of Neuroimmunology
Volume41
Issue number1
DOIs
Publication statusPublished - 1992

Fingerprint

Median Eminence
Norepinephrine
Tumor Necrosis Factor-alpha
Corticotropin-Releasing Hormone
Presynaptic Terminals
Neurotransmitter Agents
Shock
Spleen
Perfusion

Keywords

  • Median eminence
  • Neuro-immune communication
  • Noradrenaline release
  • Presynaptic modulation
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Presynaptic inhibitory effect of TNF-α on the release of noradrenaline in isolated median eminence. / Elenkov, I. J.; Kovács, K.; Duda, E.; Stark, E.; Vízi, E.

In: Journal of Neuroimmunology, Vol. 41, No. 1, 1992, p. 117-120.

Research output: Contribution to journalArticle

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AU - Duda, E.

AU - Stark, E.

AU - Vízi, E.

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