Presynaptic inhibitory effect of noradrenaline and dopamine in the central nervous system and the role of membrane ATPase

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Abstract

The question arises what is the role of presynaptic α-adrenoceptors located on noradrenergic and cholinergic neurons? It seems very likely that the role of presynaptic α-adrenoceptors of noradrenergic neurons is to keep constant the output per time unit, α-adrenoceptors located on cholinergic neurons, however, play an important role in the modulation of neurochemical transmission: NA released from the adjacent noradrenergic axon terminal presynaptically controls the release of ACh, the cholinergic transmission. In Fig. 5 {A figure is presented} is shown the role of membrane ATPase in transmitter release and in inhibitory effect of catecholamines. Calcium crossing the membrane during action potential inhibits membrane ATPase therefore the membrane becomes diffusable, catecholamines, however, being able to stimulate enzyme activity-possibly via stimulation of α-adrenoceptors-reduce the release of transmitters.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalAdvances in the Biosciences
Volume18
Issue numberC
Publication statusPublished - 1979

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Adrenergic Receptors
Adenosine Triphosphatases
Dopamine
Norepinephrine
Central Nervous System
Adrenergic Neurons
Cholinergic Neurons
Membranes
Catecholamines
Presynaptic Terminals
Cholinergic Agents
Action Potentials
Calcium
Enzymes

Cite this

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title = "Presynaptic inhibitory effect of noradrenaline and dopamine in the central nervous system and the role of membrane ATPase",
abstract = "The question arises what is the role of presynaptic α-adrenoceptors located on noradrenergic and cholinergic neurons? It seems very likely that the role of presynaptic α-adrenoceptors of noradrenergic neurons is to keep constant the output per time unit, α-adrenoceptors located on cholinergic neurons, however, play an important role in the modulation of neurochemical transmission: NA released from the adjacent noradrenergic axon terminal presynaptically controls the release of ACh, the cholinergic transmission. In Fig. 5 {A figure is presented} is shown the role of membrane ATPase in transmitter release and in inhibitory effect of catecholamines. Calcium crossing the membrane during action potential inhibits membrane ATPase therefore the membrane becomes diffusable, catecholamines, however, being able to stimulate enzyme activity-possibly via stimulation of α-adrenoceptors-reduce the release of transmitters.",
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T1 - Presynaptic inhibitory effect of noradrenaline and dopamine in the central nervous system and the role of membrane ATPase

AU - Vízi, E.

AU - Hársing, L.

PY - 1979

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N2 - The question arises what is the role of presynaptic α-adrenoceptors located on noradrenergic and cholinergic neurons? It seems very likely that the role of presynaptic α-adrenoceptors of noradrenergic neurons is to keep constant the output per time unit, α-adrenoceptors located on cholinergic neurons, however, play an important role in the modulation of neurochemical transmission: NA released from the adjacent noradrenergic axon terminal presynaptically controls the release of ACh, the cholinergic transmission. In Fig. 5 {A figure is presented} is shown the role of membrane ATPase in transmitter release and in inhibitory effect of catecholamines. Calcium crossing the membrane during action potential inhibits membrane ATPase therefore the membrane becomes diffusable, catecholamines, however, being able to stimulate enzyme activity-possibly via stimulation of α-adrenoceptors-reduce the release of transmitters.

AB - The question arises what is the role of presynaptic α-adrenoceptors located on noradrenergic and cholinergic neurons? It seems very likely that the role of presynaptic α-adrenoceptors of noradrenergic neurons is to keep constant the output per time unit, α-adrenoceptors located on cholinergic neurons, however, play an important role in the modulation of neurochemical transmission: NA released from the adjacent noradrenergic axon terminal presynaptically controls the release of ACh, the cholinergic transmission. In Fig. 5 {A figure is presented} is shown the role of membrane ATPase in transmitter release and in inhibitory effect of catecholamines. Calcium crossing the membrane during action potential inhibits membrane ATPase therefore the membrane becomes diffusable, catecholamines, however, being able to stimulate enzyme activity-possibly via stimulation of α-adrenoceptors-reduce the release of transmitters.

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