Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron

P. Kása, Henrietta Papp, Zsuzsanna Beke, David Vadasz, Janos Zombori

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It is assumed that the amyloid-beta peptide (Aβ) contributes to the neurodegeneration in Alzheimer's disease (AD). Activation of an apoptotic pathway may play a key role in this process. The apoptotic signal may be driven by caspases. The presynaptic Aβ protein may be an activator of caspase-3 and could initiate a series of cascade events, which results in neurofibrillary degeneration in a postsynaptic cell. We report here that the axonic Aβ in the AD brain may be associated with caspase-3 activation. Our data suggest that caspase-3 in fact has a significant role in the widespread neuronal cell death that occurs in AD brain. A subset of pyramidal cells in hippocampus area CA1 demonstrated widespread accumulation of tau-protein. Individual postsynaptic neurons contained intracellular activated caspase-3 and were co-localized with neurofibrillary tangles. The results presented here support the suggestion that caspase-3 activation may lead to the neuronal cell death associated with AD. However, we are aware that, besides Aβ, other factors too may initiate a series of events which lead to the development of neurofibrillary tangles in the postsynaptic neurons.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalActa Biologica Szegediensis
Volume48
Issue number1-4
Publication statusPublished - 2004

Fingerprint

caspase-3
amyloid
Amyloid
Caspase 3
Neurons
Alzheimer disease
neurons
Chemical activation
Alzheimer Disease
Neurofibrillary Tangles
Cell death
cell death
Brain
Cell Death
brain
tau Proteins
Pyramidal Cells
Amyloid beta-Peptides
caspases
hippocampus

Keywords

  • Alzheimer's disease
  • Amyloid-beta
  • Apoptosis
  • Caspase-3
  • Neurofibrillary tangle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology
  • Neuroscience(all)
  • Applied Microbiology and Biotechnology

Cite this

Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron. / Kása, P.; Papp, Henrietta; Beke, Zsuzsanna; Vadasz, David; Zombori, Janos.

In: Acta Biologica Szegediensis, Vol. 48, No. 1-4, 2004, p. 1-6.

Research output: Contribution to journalArticle

Kása, P. ; Papp, Henrietta ; Beke, Zsuzsanna ; Vadasz, David ; Zombori, Janos. / Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron. In: Acta Biologica Szegediensis. 2004 ; Vol. 48, No. 1-4. pp. 1-6.
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