Pressurization effects on the polymorphic forms of famotidine

Zoltán Német, Béla Hegedus, Csaba Szántay, Janisz Sztatisz, G. Pokol

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effects of high static pressure on the polymorphic modifications A and B of famotidine were examined by differential scanning calorimetry, infrared and Raman spectroscopy, and X-ray powder diffractometry. The obtained effects appeared to differ significantly depending on whether they were monitored by DSC or any of the other above techniques. In particular, DSC measurements tend to deceptively amplify a tendency of the pure modification B to turn into the more stable form A under pressurization, while the spectroscopic methods and XRPD exhibit no essential change in the crystal structure of the metastable form B. The apparent morphological transformation in the pressed samples stems from the nature of the DSC method itself.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalThermochimica Acta
Volume430
Issue number1-2
DOIs
Publication statusPublished - Jun 2005

Fingerprint

Famotidine
Pressurization
Powders
Raman spectroscopy
Differential scanning calorimetry
Infrared spectroscopy
Crystal structure
X rays
static pressure
stems
tendencies
heat measurement
infrared spectroscopy
crystal structure
scanning
spectroscopy
x rays

Keywords

  • Complex analytical approach
  • Differential scanning calorimetry
  • Famotidine
  • Polymorphism
  • Pressurization

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Chemistry (miscellaneous)

Cite this

Pressurization effects on the polymorphic forms of famotidine. / Német, Zoltán; Hegedus, Béla; Szántay, Csaba; Sztatisz, Janisz; Pokol, G.

In: Thermochimica Acta, Vol. 430, No. 1-2, 06.2005, p. 35-41.

Research output: Contribution to journalArticle

Német, Z, Hegedus, B, Szántay, C, Sztatisz, J & Pokol, G 2005, 'Pressurization effects on the polymorphic forms of famotidine', Thermochimica Acta, vol. 430, no. 1-2, pp. 35-41. https://doi.org/10.1016/j.tca.2004.12.009
Német, Zoltán ; Hegedus, Béla ; Szántay, Csaba ; Sztatisz, Janisz ; Pokol, G. / Pressurization effects on the polymorphic forms of famotidine. In: Thermochimica Acta. 2005 ; Vol. 430, No. 1-2. pp. 35-41.
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