Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn α chain

Yaofeng Zhao, Imre Kacskovics, Zhihui Zhao, Lennart Hammarström

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8 Citations (Scopus)

Abstract

The sequence of the pig FcRn α chain was recently published. The lack of a conserved di-leucine motif in the cytoplasmic tail suggests a rare polymorphism in the described animal, alternatively, a sequencing error. We therefore cloned and sequenced the pig FcRn α chain. Our sequence, along with a previous NCBI GenBank submission and five pig derived EST clones clearly demonstrate the presence of di-leucine motif in the cytoplasmic tail of the pig FcRn. No polymorphism in the cytoplasmic tail-encoding region was found in 25 animals from six pig breeds based on single-stranded conformation polymorphism and sequencing analysis, suggesting that the previously described pig FcRn α chain may represent a sequencing error in the 3′ portion of the gene.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume96
Issue number3-4
DOIs
Publication statusPublished - Dec 15 2003

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Keywords

  • Cytoplasmic tail
  • FcRn
  • Pig

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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