Presence of cell-free fetal DNA in plasma of women with ectopic pregnancies

Levente Lázár, B. Nagy, Z. Bán, Gyula R. Nagy, Z. Papp

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The quantity of cell-free fetal DNA in the plasma of pregnant women changes during pregnancy and seems to be different in normal and pathologic pregnancies. We investigated the possible diagnostic applications of the detection and measurement of cell-free fetal DNA by comparing quantities found in women with ectopic (EP) or intrauterine (IUP) pregnancies. Methods: We collected blood samples from 58 women who had positive pregnancy tests and specific complaints and sonographic findings suggestive of EP and from 45 women with confirmed IUP. We performed quantitative real-time PCR analysis of the sex-determining region Y (SRY) gene to detect and measure the amount of cell-free fetal DNA. The diagnosis of EP was confirmed by histologic examination. Results: SRY was detected in 15 EP and 14 IUP cases. The mean (SD) amount of cell-free fetal DNA was significantly higher (P

Original languageEnglish
Pages (from-to)1599-1601
Number of pages3
JournalClinical Chemistry
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Ectopic Pregnancy
Plasmas
DNA
Pregnancy
sry Genes
Pregnancy Tests
Real-Time Polymerase Chain Reaction
Pregnant Women
Blood
Genes

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Presence of cell-free fetal DNA in plasma of women with ectopic pregnancies. / Lázár, Levente; Nagy, B.; Bán, Z.; Nagy, Gyula R.; Papp, Z.

In: Clinical Chemistry, Vol. 52, No. 8, 08.2006, p. 1599-1601.

Research output: Contribution to journalArticle

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