Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge

Katharina Lenz, Stephan Hann, Gunda Koellensperger, Z. Stefánka, Gerhard Stingeder, Norbert Weissenbacher, Susanne N. Mahnik, Maria Fuerhacker

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Platinum originating from the excreted cancerostatic platinum compounds (CPC) cisplatin, carboplatin and oxaliplatin was monitored over a period of 28 days in the wastewater of the oncologic ward of the Vienna University Hospital. Concentration levels ranging from 4.7 to 145 μg L-1 were measured by inductively coupled plasma mass spectrometry (ICP-MS). An average ratio of weekly drug emission/drug consumption of 0.27±0.12 was assessed. Model studies were carried out for fundamental understanding of CPC interaction with the solid phases present at different stages of the water cycle. Wastewater and activated sludge were spiked with CPC at concentration levels as found in the sewer of the oncologic ward. The platinum concentration remaining in the tested solution was measured after 24 h of incubation. Depending on pH, the three substances exhibited considerably different adsorption rates in wastewater. At pH 7, cisplatin was adsorbed by 88%, whereas only 26% of carboplatin and 54% of oxaliplatin were removed from the aqueous phase. Adsorption by activated sludge was higher, less affected by pH variation and comparable for all investigated CPC (96% for cisplatin, 70% for carboplatin and 74% for oxaliplatin at pH 6.8). In a next step, the dependence of CPC adsorption was tested for wastewater and activated sludge of different sampling sites. Strong variations were found only for wastewater, whereas activated sludge showed more consistent elimination rates (average values: cisplatin 92%, carboplatin 72%, and oxaliplatin 78%). These findings indicate that the major part of the excreted CPC is adsorbed by the solid phase in the water cycle and is thus expected to be removed from the wastewater by sewage treatment plants.

Original languageEnglish
Pages (from-to)141-152
Number of pages12
JournalScience of the Total Environment
Volume345
Issue number1-3
DOIs
Publication statusPublished - Jun 1 2005

Fingerprint

oxaliplatin
Platinum compounds
Platinum Compounds
platinum
activated sludge
Wastewater
Carboplatin
adsorption
Adsorption
wastewater
Cisplatin
Platinum
Sewage treatment plants
Inductively coupled plasma mass spectrometry
drug
Water
Sewers
Pharmaceutical Preparations
hospital
sewage treatment

Keywords

  • Activated sludge
  • Adsorption
  • Cancerostatic platinum compounds
  • Hospital wastewater

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge. / Lenz, Katharina; Hann, Stephan; Koellensperger, Gunda; Stefánka, Z.; Stingeder, Gerhard; Weissenbacher, Norbert; Mahnik, Susanne N.; Fuerhacker, Maria.

In: Science of the Total Environment, Vol. 345, No. 1-3, 01.06.2005, p. 141-152.

Research output: Contribution to journalArticle

Lenz, Katharina ; Hann, Stephan ; Koellensperger, Gunda ; Stefánka, Z. ; Stingeder, Gerhard ; Weissenbacher, Norbert ; Mahnik, Susanne N. ; Fuerhacker, Maria. / Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge. In: Science of the Total Environment. 2005 ; Vol. 345, No. 1-3. pp. 141-152.
@article{b3b7a9d9f7914fe58acc15eacdce51c8,
title = "Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge",
abstract = "Platinum originating from the excreted cancerostatic platinum compounds (CPC) cisplatin, carboplatin and oxaliplatin was monitored over a period of 28 days in the wastewater of the oncologic ward of the Vienna University Hospital. Concentration levels ranging from 4.7 to 145 μg L-1 were measured by inductively coupled plasma mass spectrometry (ICP-MS). An average ratio of weekly drug emission/drug consumption of 0.27±0.12 was assessed. Model studies were carried out for fundamental understanding of CPC interaction with the solid phases present at different stages of the water cycle. Wastewater and activated sludge were spiked with CPC at concentration levels as found in the sewer of the oncologic ward. The platinum concentration remaining in the tested solution was measured after 24 h of incubation. Depending on pH, the three substances exhibited considerably different adsorption rates in wastewater. At pH 7, cisplatin was adsorbed by 88{\%}, whereas only 26{\%} of carboplatin and 54{\%} of oxaliplatin were removed from the aqueous phase. Adsorption by activated sludge was higher, less affected by pH variation and comparable for all investigated CPC (96{\%} for cisplatin, 70{\%} for carboplatin and 74{\%} for oxaliplatin at pH 6.8). In a next step, the dependence of CPC adsorption was tested for wastewater and activated sludge of different sampling sites. Strong variations were found only for wastewater, whereas activated sludge showed more consistent elimination rates (average values: cisplatin 92{\%}, carboplatin 72{\%}, and oxaliplatin 78{\%}). These findings indicate that the major part of the excreted CPC is adsorbed by the solid phase in the water cycle and is thus expected to be removed from the wastewater by sewage treatment plants.",
keywords = "Activated sludge, Adsorption, Cancerostatic platinum compounds, Hospital wastewater",
author = "Katharina Lenz and Stephan Hann and Gunda Koellensperger and Z. Stef{\'a}nka and Gerhard Stingeder and Norbert Weissenbacher and Mahnik, {Susanne N.} and Maria Fuerhacker",
year = "2005",
month = "6",
day = "1",
doi = "10.1016/j.scitotenv.2004.11.007",
language = "English",
volume = "345",
pages = "141--152",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge

AU - Lenz, Katharina

AU - Hann, Stephan

AU - Koellensperger, Gunda

AU - Stefánka, Z.

AU - Stingeder, Gerhard

AU - Weissenbacher, Norbert

AU - Mahnik, Susanne N.

AU - Fuerhacker, Maria

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Platinum originating from the excreted cancerostatic platinum compounds (CPC) cisplatin, carboplatin and oxaliplatin was monitored over a period of 28 days in the wastewater of the oncologic ward of the Vienna University Hospital. Concentration levels ranging from 4.7 to 145 μg L-1 were measured by inductively coupled plasma mass spectrometry (ICP-MS). An average ratio of weekly drug emission/drug consumption of 0.27±0.12 was assessed. Model studies were carried out for fundamental understanding of CPC interaction with the solid phases present at different stages of the water cycle. Wastewater and activated sludge were spiked with CPC at concentration levels as found in the sewer of the oncologic ward. The platinum concentration remaining in the tested solution was measured after 24 h of incubation. Depending on pH, the three substances exhibited considerably different adsorption rates in wastewater. At pH 7, cisplatin was adsorbed by 88%, whereas only 26% of carboplatin and 54% of oxaliplatin were removed from the aqueous phase. Adsorption by activated sludge was higher, less affected by pH variation and comparable for all investigated CPC (96% for cisplatin, 70% for carboplatin and 74% for oxaliplatin at pH 6.8). In a next step, the dependence of CPC adsorption was tested for wastewater and activated sludge of different sampling sites. Strong variations were found only for wastewater, whereas activated sludge showed more consistent elimination rates (average values: cisplatin 92%, carboplatin 72%, and oxaliplatin 78%). These findings indicate that the major part of the excreted CPC is adsorbed by the solid phase in the water cycle and is thus expected to be removed from the wastewater by sewage treatment plants.

AB - Platinum originating from the excreted cancerostatic platinum compounds (CPC) cisplatin, carboplatin and oxaliplatin was monitored over a period of 28 days in the wastewater of the oncologic ward of the Vienna University Hospital. Concentration levels ranging from 4.7 to 145 μg L-1 were measured by inductively coupled plasma mass spectrometry (ICP-MS). An average ratio of weekly drug emission/drug consumption of 0.27±0.12 was assessed. Model studies were carried out for fundamental understanding of CPC interaction with the solid phases present at different stages of the water cycle. Wastewater and activated sludge were spiked with CPC at concentration levels as found in the sewer of the oncologic ward. The platinum concentration remaining in the tested solution was measured after 24 h of incubation. Depending on pH, the three substances exhibited considerably different adsorption rates in wastewater. At pH 7, cisplatin was adsorbed by 88%, whereas only 26% of carboplatin and 54% of oxaliplatin were removed from the aqueous phase. Adsorption by activated sludge was higher, less affected by pH variation and comparable for all investigated CPC (96% for cisplatin, 70% for carboplatin and 74% for oxaliplatin at pH 6.8). In a next step, the dependence of CPC adsorption was tested for wastewater and activated sludge of different sampling sites. Strong variations were found only for wastewater, whereas activated sludge showed more consistent elimination rates (average values: cisplatin 92%, carboplatin 72%, and oxaliplatin 78%). These findings indicate that the major part of the excreted CPC is adsorbed by the solid phase in the water cycle and is thus expected to be removed from the wastewater by sewage treatment plants.

KW - Activated sludge

KW - Adsorption

KW - Cancerostatic platinum compounds

KW - Hospital wastewater

UR - http://www.scopus.com/inward/record.url?scp=20344388300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20344388300&partnerID=8YFLogxK

U2 - 10.1016/j.scitotenv.2004.11.007

DO - 10.1016/j.scitotenv.2004.11.007

M3 - Article

C2 - 15919535

AN - SCOPUS:20344388300

VL - 345

SP - 141

EP - 152

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

IS - 1-3

ER -