Presence of anti-microbial antibodies in liver cirrhosis - A tell-tale sign of compromised immunity?

Maria Papp, Gary L. Norman, Zsuzsanna Vitalis, Istvan Tornai, Istvan Altorjay, Ildiko Foldi, Miklos Udvardy, Zakera Shums, Tamas Dinya, Peter Orosz, Bela Lombay, Gabriella Par, Alajos Par, Gabor Veres, Timea Csak, Janos Osztovits, Ferenc Szalay, Peter Laszlo Lakatos

Research output: Contribution to journalArticle

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Abstract

Background: Bacterial translocation plays important role in the complications of liver cirrhosis. Antibody formation against various microbial antigens is common in Crohn's disease and considered to be caused by sustained exposure to gut microflora constituents. We hypothesized that anti-microbial antibodies are present in patients with liver cirrhosis and may be associated with the development of bacterial infections. Methodology/Principal Findings: Sera of 676 patients with various chronic liver diseases (autoimmune diseases:266, viral hepatitis C:124, and liver cirrhosis of different etiology:286) and 100 controls were assayed for antibodies to Saccharomyces cerevisiae(ASCA) and to antigens derived from two intestinal bacterial isolates (one gram positive, one gram negative, neither is Escherichia coli). In patients with liver cirrhosis, we also prospectively recorded the development of severe episodes of bacterial infection. ASCA and anti-OMP PlusTM antibodies were present in 38.5% and 62.6% of patients with cirrhosis and in 16% and 20% of controls, respectively (p

Original languageEnglish
Article numbere12957
JournalPLoS One
Volume5
Issue number9
DOIs
Publication statusPublished - 2010

Fingerprint

liver cirrhosis
Liver Cirrhosis
Liver
Anti-Idiotypic Antibodies
Immunity
immunity
antibodies
Antibodies
bacterial infections
Bacterial Infections
Saccharomyces cerevisiae
Yeast
viral hepatitis
antigens
hepatitis C
Bacterial Translocation
Antigens
Crohn disease
autoimmune diseases
liver diseases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Presence of anti-microbial antibodies in liver cirrhosis - A tell-tale sign of compromised immunity? / Papp, Maria; Norman, Gary L.; Vitalis, Zsuzsanna; Tornai, Istvan; Altorjay, Istvan; Foldi, Ildiko; Udvardy, Miklos; Shums, Zakera; Dinya, Tamas; Orosz, Peter; Lombay, Bela; Par, Gabriella; Par, Alajos; Veres, Gabor; Csak, Timea; Osztovits, Janos; Szalay, Ferenc; Lakatos, Peter Laszlo.

In: PLoS One, Vol. 5, No. 9, e12957, 2010.

Research output: Contribution to journalArticle

Papp, Maria ; Norman, Gary L. ; Vitalis, Zsuzsanna ; Tornai, Istvan ; Altorjay, Istvan ; Foldi, Ildiko ; Udvardy, Miklos ; Shums, Zakera ; Dinya, Tamas ; Orosz, Peter ; Lombay, Bela ; Par, Gabriella ; Par, Alajos ; Veres, Gabor ; Csak, Timea ; Osztovits, Janos ; Szalay, Ferenc ; Lakatos, Peter Laszlo. / Presence of anti-microbial antibodies in liver cirrhosis - A tell-tale sign of compromised immunity?. In: PLoS One. 2010 ; Vol. 5, No. 9.
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abstract = "Background: Bacterial translocation plays important role in the complications of liver cirrhosis. Antibody formation against various microbial antigens is common in Crohn's disease and considered to be caused by sustained exposure to gut microflora constituents. We hypothesized that anti-microbial antibodies are present in patients with liver cirrhosis and may be associated with the development of bacterial infections. Methodology/Principal Findings: Sera of 676 patients with various chronic liver diseases (autoimmune diseases:266, viral hepatitis C:124, and liver cirrhosis of different etiology:286) and 100 controls were assayed for antibodies to Saccharomyces cerevisiae(ASCA) and to antigens derived from two intestinal bacterial isolates (one gram positive, one gram negative, neither is Escherichia coli). In patients with liver cirrhosis, we also prospectively recorded the development of severe episodes of bacterial infection. ASCA and anti-OMP PlusTM antibodies were present in 38.5{\%} and 62.6{\%} of patients with cirrhosis and in 16{\%} and 20{\%} of controls, respectively (p",
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AU - Vitalis, Zsuzsanna

AU - Tornai, Istvan

AU - Altorjay, Istvan

AU - Foldi, Ildiko

AU - Udvardy, Miklos

AU - Shums, Zakera

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AU - Orosz, Peter

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AU - Par, Gabriella

AU - Par, Alajos

AU - Veres, Gabor

AU - Csak, Timea

AU - Osztovits, Janos

AU - Szalay, Ferenc

AU - Lakatos, Peter Laszlo

PY - 2010

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