Presence of an atrial natriuretic factor-like peptide in the rat superior cervical ganglia

W. Debinski, J. Gutkowska, O. Kuchel, K. Racz, N. T. Buu, M. Cantin, J. Genest

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Abstract

The presence of a peptide resembling atrial natriuretic factor (ANF) was demonstrated in the peripheral sympathetic ganglia of the rat by a sensitive radioimmunoassay. Partially purified ANF-like compounds from the superior cervical ganglia exhibited biological activities which were similar to the synthetic peptide of cardiac origin; they inhibited ACTH-stimulated aldosterone release in vitro and displaced labelled [125I]-ANF from rat adrenocortical cell receptors. The exact source and role of ANF in peripheral nervous structures is not fully understood. We suggest that in sympathetic ganglia ANF may act as a neurotransmitter and/or neuromodulator in a manner similar to other neuropeptides.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalNeuroendocrinology
Volume46
Issue number3
DOIs
Publication statusPublished - Jan 1 1987

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Debinski, W., Gutkowska, J., Kuchel, O., Racz, K., Buu, N. T., Cantin, M., & Genest, J. (1987). Presence of an atrial natriuretic factor-like peptide in the rat superior cervical ganglia. Neuroendocrinology, 46(3), 236-240. https://doi.org/10.1159/000124825