Presence and localization of epidermal growth factor (EGF)- and EGF-receptor-like immunoreactivity in Tetrahymena

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Abstract

The presence of EGF- and EGF-receptor-like immunoreactivity in Tetrahymena was studied with the help of FITC-labelled monoclonal antibodies, using flow cytometry and confocal microscopy. Tetrahymena has endogeneous EGF and treatment with it significantly increases the hormone content of the cells. The hormone is diffusely localized, particularly in the cytopharynx, where it forms a structure larger than 10μm. EGF-receptors are also demonstrable, particularly in the cortical region in connection with cilia, and EGF treatment significantly enhances cortical fluorescence. The relationships between these observations and literary data on the effects of EGF in Tetrahymena are discussed.

Original languageEnglish
Pages (from-to)491-496
Number of pages6
JournalCell biology international
Volume28
Issue number7
DOIs
Publication statusPublished - Jul 1 2004

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Keywords

  • EGF
  • EGF-receptor
  • EGF-treatment
  • Hormones
  • Phylogeny
  • Tetrahymena

ASJC Scopus subject areas

  • Cell Biology

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