Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions

Éva Bölcskei, Géza Regdon, Tamás Sovány, Dima Ghanam, Klaus Knop, Peter Kleinebudde, Klára Pintye-Hódi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: The focus of this work was to produce matrix pellets made by extrusion/ spheronization using two types of equipment. The aim was to accomplish the laboratory-scale I process that has been already optimized and accepted with another type of equipment (laboratory-scale II). Methods: A matrix pellet formulation consisting of MCC, Eudragit NE 30D and diclofenac sodium was used in the two types of equipment. Physico-chemical parameters and the dissolution profiles of the pellets in phosphate buffer pH 6.8 were compared. Results: Pellets from both processes were similar in shape and tensile strength. They differed in particle size and dissolution profile. This may be contributed to different spheronization conditions.

Original languageEnglish
Pages (from-to)762-764
Number of pages3
JournalDrug development and industrial pharmacy
Volume40
Issue number6
DOIs
Publication statusPublished - Jun 2014

Keywords

  • Aspect ratio
  • Dissolution
  • Extrusion/spheronization
  • Pellets
  • Tensile strength

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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