Preparation of synthetic oligosaccharide-conjugates of poly-β- (1→6)-N-acetyl glucosamine

Anikó Fekete, Dániel Eszenyi, Mihály Herczeg, Vince Pozsgay, A. Borbás

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Staphylococcus aureus and Staphylococcus epidermidis are prominent bacterial pathogens of nosocomial infections. Both microorganisms colonize medical devices by forming adherent biofilms. Poly-β-d-(1→6)-N-acetyl- glucosamine (PNAG) is a surface polysaccharide antigen which was found on both S. aureus and S. epidermidis. Animal studies have proved that PNAG can elicit antibodies which protect against staphylococcal infections. We have presented the synthesis of di-, tetra- and hexasaccharide fragments of PNAG with formyl-heptyl aglycone and their attachment to bovine serum albumin (BSA) by reductive amination.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalCarbohydrate Research
Volume386
Issue number1
DOIs
Publication statusPublished - Mar 11 2014

Fingerprint

Amination
Staphylococcus epidermidis
Glucosamine
Biofilms
Pathogens
Bovine Serum Albumin
Oligosaccharides
Microorganisms
Polysaccharides
Staphylococcus aureus
Animals
Antigens
Staphylococcal Infections
Antibodies
Surface Antigens
Cross Infection
Equipment and Supplies
poly-N-acetyl glucosamine

Keywords

  • Carbohydrate chemical synthesis
  • Glycoconjugate
  • Poly-β-(1→6)-N-acetyl glucosamine
  • Reductive amination

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Preparation of synthetic oligosaccharide-conjugates of poly-β- (1→6)-N-acetyl glucosamine. / Fekete, Anikó; Eszenyi, Dániel; Herczeg, Mihály; Pozsgay, Vince; Borbás, A.

In: Carbohydrate Research, Vol. 386, No. 1, 11.03.2014, p. 33-40.

Research output: Contribution to journalArticle

Fekete, Anikó ; Eszenyi, Dániel ; Herczeg, Mihály ; Pozsgay, Vince ; Borbás, A. / Preparation of synthetic oligosaccharide-conjugates of poly-β- (1→6)-N-acetyl glucosamine. In: Carbohydrate Research. 2014 ; Vol. 386, No. 1. pp. 33-40.
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