Preparation of [99mTc]TRODAT-1 involving a simple purification method

Gyula Tóth, Zsolt Szakonyi, Balázs Kanyó, Ferenc Fülöp, Gábor Jancsó, László Pávics

Research output: Contribution to journalArticle

3 Citations (Scopus)


Direct preparation of the novel dopamine transporter imaging agent [ 99mTc]TRODAT-1 results in uncertainty concerning the labelling efficiency. Without purification of the tracer, the statistically inefficient labelling yield becomes apparent in an inadequate radiochemical purity. The aim of the present work was to improve the radiochemical purity of this tracer by including a facile, on-the-spot purification step in the labelling process. Kits containing 100 μg free ligand resulted in an average labelling efficiency of 91.6% (S.D. = 5.15%, n = 32), while an average of 73.0% (S.D. = 6.76%, n = 22) was obtained for the 50 μg ligand series. Introduction of solid-phase extraction into the preparation process allowed the quantitative removal of hydrophilic species from both series of reaction mixtures. An average radiochemical purity of 98% was achieved for the purified tracer.

Original languageEnglish
Pages (from-to)1067-1073
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number11
Publication statusPublished - Oct 1 2003


  • Kit preparation dopamine transporters
  • TRODAT-1 solid-phase extraction
  • Technetium-99m

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Preparation of [<sup>99m</sup>Tc]TRODAT-1 involving a simple purification method'. Together they form a unique fingerprint.

  • Cite this