Preparation of quercetin delivery systems on the basis of amino-modified KIL-2 mesoporous silica

M. Popova, I. Trendafilova, I. Tsacheva, N. Georgieva, N. Koseva, A. Szegedi, J. Mihály, N. Novak-Tusar

Research output: Contribution to journalArticle

Abstract

KIL-2 silica with textural mesoporosity was synthesized and modified with amino groups by post-synthesis method. Quercetin was successfully loaded on amino-modified KIL-2 by incipient wetness impregnation or solid-state method. Quercetin-loaded KIL-2NH2 particles were coated by a polyelectrolyte polymer complex containing κ-carrageenanchitosan- κ-carrageenan. The parent, amino-modified and quercetin loaded samples were characterized by XRD, N2 physisorption, thermal gravimetric analysis and ATR-FT-IR spectroscopy. In-vitro release of quercetin from quercetin loaded formulations was studied in two acceptor media resembling physiological pH GIT (pH=1.2 and pH=6.8). The invitro release study showed slower quercetin release from polymer coated quercetin-loaded KIL-2NH2 samples prepared by both methods compared to the uncoated ones.

Original languageEnglish
Pages (from-to)190-194
Number of pages5
JournalBulgarian Chemical Communications
Volume50
Publication statusPublished - Jan 1 2018

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Keywords

  • In-vitro release
  • Modified mesoporous silica kil-2NH
  • Oral administration
  • Quercetin delivery

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Popova, M., Trendafilova, I., Tsacheva, I., Georgieva, N., Koseva, N., Szegedi, A., Mihály, J., & Novak-Tusar, N. (2018). Preparation of quercetin delivery systems on the basis of amino-modified KIL-2 mesoporous silica. Bulgarian Chemical Communications, 50, 190-194.