Preparation of pyridine N-oxide derivatives in microreactor

Attila Vörös, Géza Timári, Zoltán Baán, Péter Mizsey, Zoltán Finta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

N-oxidations of different nitrogen-containing heterocyclic molecules are often applied for synthetic transformations in chemistry. The industrial implementation of classical batch oxidation processes are limited due to safety concerns derived from metal ion catalyzed decompositions. These restrictions and other safety concern issues can be minimized or even avoided by applying glass made microreactor setups for this transformation. The N-oxidation of different pyridine derivative, quinoline and isoquinoline is studied using two popular oxidizing reagents. The further transformation of pyridine derivatives is studied through the Polonovski rearrangement in microreactor.

Original languageEnglish
Pages (from-to)195-205
Number of pages11
JournalPeriodica Polytechnica Chemical Engineering
Volume58
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Microreactor technology
  • N-oxide
  • Oxidation
  • Polonovski rearrangement
  • Safety concern reaction

ASJC Scopus subject areas

  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Preparation of pyridine N-oxide derivatives in microreactor'. Together they form a unique fingerprint.

  • Cite this