Preparation of pellets containing theophylline

Zsolt Muskó, János Bajdik, Klára Pintye-Hódi, Piroska Szabó-Révész, András Kelemen, István Eros

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The aim of this work was to prepare theophylline (CAS 5967-84-0) pellets by using a centrifugal granulator. Theophylline crystals have unsuitable powder rheological properties. Wet granulation was necessary and pellets with different particle sizes were prepared. The habit of the pellets was spherical, with a compact texture. The process of pellet deformation was tested by means of a modified equipment, and the force-time curve is presented. Use of a centrifugal granulator with the parameters applied resulted in theophylline pellets with suitable parameters (shape, texture, deformation behaviour and dissolution). The particle size influenced the flow properties and the deformation parameters but it had no influence on the dissolution rate of active agent.

Original languageEnglish
Pages (from-to)1194-1198
Number of pages5
JournalPharmazeutische Industrie
Issue number11
Publication statusPublished - Jan 1 2002



  • CAS 5967-84-0
  • Centrifugal granulator
  • Pellets, deformation, flow properties, particle size
  • Theophylline

ASJC Scopus subject areas

  • Pharmaceutical Science

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