A new method for the resolution of pipecolic acid, a non-proteinogenic amino acid frequently occurring in plants, is described. Six new benzyloxycarbonyl derivatives, four activated esters of benzyloxycarbonyl l- and d-pipecolic acid and the o-nitrophenylsulfenyl and t-butoxycarbonyl derivatives of l- and d-pipecolic acid, useful for the synthesis of biologically active oligopeptides, were prepared. The physical constants of pure l- and d-pipecolic acid are reported.
|Translated title of the contribution||Preparation of optically active pipecolic acid derivatives suitable for peptide synthesis|
|Number of pages||7|
|Journal||Monatshefte für Chemie|
|Publication status||Published - Jul 1 1970|
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