Preparation of molecularly imprinted microspheres by precipitation polymerization

Tibor Renkecz, V. Horváth

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Molecularly imprinted polymers (MIPs) gained an expansively growing interest in the past few decades. After an initial, explorative period of preparing MIPs exclusively with bulk polymerization, new polymer synthesis routes have been adapted to overcome the drawbacks of the traditional method. Among these the most appealing is precipitation polymerization that results in nano- and microspheres with narrow size distribution and makes the production of MIPs more straightforward. Here, we describe a precipitation polymerization protocol for a common small molecule template, propranolol that is carried out in the conventional way, in dilute monomer solution. Moreover, a modified precipitation polymerization protocol from concentrated monomer solution is presented for a diclofenac imprinted polymer which makes the synthesis even more versatile and circumvents the disadvantages of the dilute solution conditions.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages341-352
Number of pages12
Volume1575
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1575
ISSN (Print)10643745

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Keywords

  • Diclofenac
  • Modified precipitation polymerization
  • Molecularly imprinted polymer
  • Monodisperse
  • Polymer microsphere
  • Precipitation polymerization
  • Propranolol

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Renkecz, T., & Horváth, V. (2017). Preparation of molecularly imprinted microspheres by precipitation polymerization. In Methods in Molecular Biology (Vol. 1575, pp. 341-352). (Methods in Molecular Biology; Vol. 1575). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6857-2_21