Preparation of hydroxy-substituted hexahydrophthalazinones from cyclohexane- and norbornanelactones or ketallactones

József A. Szabó, P. Sohár, A. Csámpai, G. Stájer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cyclohexane- and norbomanelactones (1, 5) as well as ketallactones (3, 7) and their hydrolytic products (2, 4a,b, 8) react with hydrazine hydrate to yield the hydroxy-substituted hexahydrophthalazinones 9-12. In the cyclizations, the configurations of the bridgehead atoms remain unaltered, and the hydroxy group retains its original position in the hydrazinolysis of 5 and 7. The compounds were characterized by IR, 1H, and 13C NMR spectroscopy.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalMonatshefte fur Chemie
Volume133
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

hydrazine
Cyclization
Nuclear magnetic resonance spectroscopy
Atoms
Cyclohexane

Keywords

  • Amino acids
  • Heterocycles
  • Hydrazinolysis
  • Ketones
  • Phthalazinones

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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abstract = "Cyclohexane- and norbomanelactones (1, 5) as well as ketallactones (3, 7) and their hydrolytic products (2, 4a,b, 8) react with hydrazine hydrate to yield the hydroxy-substituted hexahydrophthalazinones 9-12. In the cyclizations, the configurations of the bridgehead atoms remain unaltered, and the hydroxy group retains its original position in the hydrazinolysis of 5 and 7. The compounds were characterized by IR, 1H, and 13C NMR spectroscopy.",
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T1 - Preparation of hydroxy-substituted hexahydrophthalazinones from cyclohexane- and norbornanelactones or ketallactones

AU - Szabó, József A.

AU - Sohár, P.

AU - Csámpai, A.

AU - Stájer, G.

PY - 2002

Y1 - 2002

N2 - Cyclohexane- and norbomanelactones (1, 5) as well as ketallactones (3, 7) and their hydrolytic products (2, 4a,b, 8) react with hydrazine hydrate to yield the hydroxy-substituted hexahydrophthalazinones 9-12. In the cyclizations, the configurations of the bridgehead atoms remain unaltered, and the hydroxy group retains its original position in the hydrazinolysis of 5 and 7. The compounds were characterized by IR, 1H, and 13C NMR spectroscopy.

AB - Cyclohexane- and norbomanelactones (1, 5) as well as ketallactones (3, 7) and their hydrolytic products (2, 4a,b, 8) react with hydrazine hydrate to yield the hydroxy-substituted hexahydrophthalazinones 9-12. In the cyclizations, the configurations of the bridgehead atoms remain unaltered, and the hydroxy group retains its original position in the hydrazinolysis of 5 and 7. The compounds were characterized by IR, 1H, and 13C NMR spectroscopy.

KW - Amino acids

KW - Heterocycles

KW - Hydrazinolysis

KW - Ketones

KW - Phthalazinones

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