Preparation of hydroxy-substituted hexahydrophthalazinones from cyclohexane- and norbornanelactones or ketallactones

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cyclohexane- and norbomanelactones (1, 5) as well as ketallactones (3, 7) and their hydrolytic products (2, 4a, b, 8) react with hydrazine hydrate to yield the hydroxy-substituted hexahydrophthalazinones 9-12. In the cyclizations, the configurations of the bridgehead atoms remain unaltered, and the hydroxy group retains its original position in the hydrazinolysis of 5 and 7. The compounds were characterized by IR, 1H, and 13C NMR spectroscopy.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalMonatshefte fur Chemie
Volume133
Issue number3
DOIs
Publication statusPublished - Jan 1 2002

Keywords

  • Amino acids
  • Heterocycles
  • Hydrazinolysis
  • Ketones
  • Phthalazinones

ASJC Scopus subject areas

  • Chemistry(all)

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