Preparation of highly enantiopure β-amino esters by Candida antarctica lipase A

Szilvia Gedey, Arto Liljeblad, László Lázár, Ferenc Fülöp, Liisa T. Kanerva

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The enantioselectivities for the reactions of aliphatic β-substituted β-amino esters [RCH(NH2)CH2CO2Et with R = Me, Et, n-Pr, i-Pr, CHEt2, cyclohexyl and Ph] with butyl butanoate in neat butyl butanoate and with 2,2,2-trifluoroethyl butanoate in diisopropyl ether were studied in the presence of Candida antarctica lipase A. Enantioselectivities ranging from good (E = 70-100) to excellent (E>100) were commonly observed, allowing gram-scale resolution of the substrates.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalTetrahedron Asymmetry
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 5 2001

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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