Preparation of a solid dispersion by a dropping method to improve the rate of dissolution of meloxicam

Amir Bashiri-Shahroodi, Parya Reisi Nassab, Piroska Szabó-Révész, Róbert Rajkó

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Application of a solid dispersion system is one of the methods used to increase the bioavailability of poorly water-soluble drugs. Adaptation of the dropping method from the chemical industry as a formulation procedure may help the scaling-up process and simplify the formulation of poorly water-soluble compounds. Meloxicam (ME), a nonsteroidal anti-inflammatory drug that is poorly soluble in water, and polyethylene glycol (PEG) 4000, a water-soluble carrier, were formulated by using a dropping method in an attempt to improve the dissolution of ME. Pure ME and physical mixtures and tablets of ME-PEG 4000 (1:3 ratio) were compared as regards their dissolution with samples formulated by the dropping method. The results revealed that the round particles (solid drops) exhibited a higher dissolution rate than those of the physical mixtures, tablets, and pure ME. Self-modeling curve resolution (SMCR) as a chemometric method was used to evaluate X-ray powder diffractometry (XRPD) data. The results demonstrated the presence of a new crystalline phase in the solid dispersion, which can help the fast and quantitative dissolution from the solid drops. The round particles can be adapted to individual therapy by using a distributor.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalDrug development and industrial pharmacy
Volume34
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

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Keywords

  • Chemometrics
  • Dissolution
  • Dropping method
  • Meloxicam
  • PEG 4000
  • Poorly water-soluble drug
  • Solid dispersion

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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