Preparation and XAFS studies of organotin(IV) complexes with adenosine and related compounds and calf thymus DNA

L. Nagy, A. Szorcsik, H. Jankovics, T. Yamaguchi, K. Yoshida, M. Scopelliti, L. Pellerito, E. Sletten

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Abstract

Complexes of adenosine and related compounds (adenosine-5′- monophosphate, adenosine-5′-triphosphate and pyridoxal-5-phosphate) with Bu2SnO and/or BuSnCl2 were prepared in the solid state. The compositions of the complexes were determined by standard analytical methods. It was found that the complexes contain the organotin(IV) moiety and the ligand in a ratio of 1:1. The FT-IR spectra demonstrated that Bu 2SnO reacts with the D-ribose moiety of the ligands, while Bu 2SnCl2 is coordinated to the deprotonated phosphate group. The basic part of the ligands does not participate directly in complex formation. Comparison of the experimental Mössbauer Δ (quadrupole splitting) values with those calculated on the basis of the pqs concept revealed that the organotin(IV) moiety has Tbp and in some cases also Th geometry. The adenosine complex contains the organotin(IV) cation in two different surroundings (Tbp and Th). The local structures of the complexes were determined by means of EXAFS measurements. At the same time a number of organotin(IV) complexes containing different organo moieties of calf thymus DNA were also prepared. Similarly as above, EXAFS data were obtained for these compounds and analyzed by using multishell models up to 300 pm. These results are the first structural data (bond lengths) on complexes formed with organotin(IV)-DNA and related compounds.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume275
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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