Preparation and structures of isoindolone- or pyrimidone-condensed heterocycles containing a hydroxy group on a cyclohexane or norbornane moiety

Ferenc Miklós, P. Sohár, A. Csámpai, Reijo Sillanpää, G. Stájer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

With DL-valinol, 3-amino-1-propanol and o-aminothiophenol, aroyl(bi/tri)cyclic lactones 1 and 2 were cyclized to isoindole- 4-6, 8, 9, pyrimidinone- 10 or thiazepine- 7 condensed heterocycles. The ketal lactone 3 furnished the benzthiazoloisoindole 9 and mixtures of epimeric hydroxyphthalazinoquinazolinones 11 and 12. The structures were established by means of 1H and 13C NMR spectroscopy and in some cases by X-ray crystallography.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalLetters in Organic Chemistry
Volume6
Issue number3
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Norbornanes
Pyrimidinones
Lactones
Thiazepines
Isoindoles
X ray crystallography
X Ray Crystallography
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Cyclohexane
Isoindol-1-one

Keywords

  • 1, 3-oxazines
  • Cycloalkane lactones
  • Isoindolones
  • NMR
  • Stereostructure
  • Thiazoles
  • X-ray

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry

Cite this

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abstract = "With DL-valinol, 3-amino-1-propanol and o-aminothiophenol, aroyl(bi/tri)cyclic lactones 1 and 2 were cyclized to isoindole- 4-6, 8, 9, pyrimidinone- 10 or thiazepine- 7 condensed heterocycles. The ketal lactone 3 furnished the benzthiazoloisoindole 9 and mixtures of epimeric hydroxyphthalazinoquinazolinones 11 and 12. The structures were established by means of 1H and 13C NMR spectroscopy and in some cases by X-ray crystallography.",
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T1 - Preparation and structures of isoindolone- or pyrimidone-condensed heterocycles containing a hydroxy group on a cyclohexane or norbornane moiety

AU - Miklós, Ferenc

AU - Sohár, P.

AU - Csámpai, A.

AU - Sillanpää, Reijo

AU - Stájer, G.

PY - 2009/4

Y1 - 2009/4

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AB - With DL-valinol, 3-amino-1-propanol and o-aminothiophenol, aroyl(bi/tri)cyclic lactones 1 and 2 were cyclized to isoindole- 4-6, 8, 9, pyrimidinone- 10 or thiazepine- 7 condensed heterocycles. The ketal lactone 3 furnished the benzthiazoloisoindole 9 and mixtures of epimeric hydroxyphthalazinoquinazolinones 11 and 12. The structures were established by means of 1H and 13C NMR spectroscopy and in some cases by X-ray crystallography.

KW - 1, 3-oxazines

KW - Cycloalkane lactones

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KW - NMR

KW - Stereostructure

KW - Thiazoles

KW - X-ray

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