Preparation and structures of isoindolone- or pyrimidone-condensed heterocycles containing a hydroxy group on a cyclohexane or norbornane moiety

Ferenc Miklós, Pál Sohár, Antal Csámpai, Reijo Sillanpää, Géza Stájer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

With DL-valinol, 3-amino-1-propanol and o-aminothiophenol, aroyl(bi/tri)cyclic lactones 1 and 2 were cyclized to isoindole- 4-6, 8, 9, pyrimidinone- 10 or thiazepine- 7 condensed heterocycles. The ketal lactone 3 furnished the benzthiazoloisoindole 9 and mixtures of epimeric hydroxyphthalazinoquinazolinones 11 and 12. The structures were established by means of 1H and 13C NMR spectroscopy and in some cases by X-ray crystallography.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalLetters in Organic Chemistry
Volume6
Issue number3
DOIs
Publication statusPublished - Apr 1 2009

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Keywords

  • 1, 3-oxazines
  • Cycloalkane lactones
  • Isoindolones
  • NMR
  • Stereostructure
  • Thiazoles
  • X-ray

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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