Lamellar lyotropic liquid crystalline systems are thermodynamically stable, optically isotropic continuous compositions composed of particles of a few nanometeres in diameter which are formed spontaneously or with a low energy input in the definite proportions of the given components. New possibilities for the development of controlled drug delivery systems are inherent in these systems in consequence of their stability and special, skinfriendly structure. The present aim was to formulate and study two- or multicomponent compositions with a relatively low surfactant content, composed of materials official in the pharmacopoeia and suitable for therapeutic purposes. Macroscopic examination of the samples was carried out, together with polarizing light microscopy and transmission electron microscopic observation of replicas produced by the freeze-fractured technique for the purpose of demonstrating the presence of lamellar liquid crystalline domains. The interlamellar repeated distance confirming the existence of a regular structure was determined by means of X-ray diffraction.
|Number of pages||6|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Aug 27 2003|
ASJC Scopus subject areas
- Pharmaceutical Science