Telitett es reszlegesen telitett izoindolo[2,1-a][3,1]benzoxazinok, -[1,2-b][2,4]benzoxazepinonok, ciklopentan- es -hexan[b]pirrolo[2,1-a][3,1]benzoxazin izomerek szintezise

Translated title of the contribution: Preparation and steric structure elucidation of saturated or partially saturated isoindolo[2,1-a]-[3,1]benzoxazinones, -[1,2-b][2,4]benzoxazepinones, cyclopentane- and -cyclohexane[b]pyrrolo[2,1-a][3,1]-benzoxazines

Géza Stájer, Miklós Virág, E. Angela Szabó, Gábor Bernáth, Pál Sohár

Research output: Contribution to journalArticle


The reactions of 2-carboxybenzaldehyde with 1,3- or 1,4-aminealcohols were used to prepare partially or fully saturated tetra- and pentacyclic compounds containing a condensed 1,3-oxazino- or oxazepinoisoindolone moiety and one terminal saturated carbocycle. Isoindolol[2,1-a][3,1]-benzoxazinones, stereoisomeric isoindolo[1,2-b][2,4]benzoxazepinones hexahydrocyclopentane[b]pyrrolo[1,2-a][3,1]-benzoxazinone, octahydroindolo[1,2-b]- and decahydroindolo[1,2-a]benzoxazinone and related pentacyclic derivatives were prepared. The diastereomers 5a-c differ in the ring annelation or in the position of the NCHO hydrogens and annelational hydrogens. The stereostructures of these compounds were elucidated by means of 1H and 13C NMR spectroscopy, including DNOE, DEPT, 2D-HSC measurements and X-ray analysis.

Original languageHungarian
Pages (from-to)201-210
Number of pages10
JournalActa pharmaceutica Hungarica
Issue number5
Publication statusPublished - Sep 1 1997


ASJC Scopus subject areas

  • Pharmaceutical Science

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