Preparation and investigation of mixtures containing lidocaine base and β-cyclodextrin

Anita Tatai, Zoltán Aigner, István Erős, Mihály Kata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of β-cyclodextrin (β-CD) on the solubility properties of lidocaine base were studied. Products were prepared by physical mixing, kneading, spray-drying and precipitation methods in drug : β-CD ratios of 3:1, 2:1, 1:1, 1:2 and 1:3. Some auxiliary materials (hydroxy acids, etc.) were also used. The solubility and the rate of dissolution both in distilled water and in artificial gastric juice, the in vitro diffusion, the thermoanalytical properties (TG, DTG, DSC and DTA) and the surface tension were determined, and the measured results were compared with the corresponding data for lidocaine hydrochloride.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume59
Issue number1-2
DOIs
Publication statusPublished - Oct 2007

Keywords

  • In vitro diffusion
  • Inclusion complexation
  • Lidocaine base
  • Rate of dissolution
  • Thermoanalytical investigations
  • β-Cyclodextrin

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Preparation and investigation of mixtures containing lidocaine base and β-cyclodextrin'. Together they form a unique fingerprint.

  • Cite this