Preparation and investigation of mixtures containing lidocaine base and β-cyclodextrin

Anita Tatai, Z. Aigner, I. Erös, Mihály Kata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of β-cyclodextrin (β-CD) on the solubility properties of lidocaine base were studied. Products were prepared by physical mixing, kneading, spray-drying and precipitation methods in drug : β-CD ratios of 3:1, 2:1, 1:1, 1:2 and 1:3. Some auxiliary materials (hydroxy acids, etc.) were also used. The solubility and the rate of dissolution both in distilled water and in artificial gastric juice, the in vitro diffusion, the thermoanalytical properties (TG, DTG, DSC and DTA) and the surface tension were determined, and the measured results were compared with the corresponding data for lidocaine hydrochloride.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalJournal of Inclusion Phenomena
Volume59
Issue number1-2
DOIs
Publication statusPublished - Oct 2007

Fingerprint

lidocaine
cyclodextrins
Cyclodextrins
Lidocaine
Solubility
solubility
kneading
juices
gastric juice
Spray drying
preparation
Hydroxy Acids
Gastric Juice
Surface Tension
spray drying
surface tension
hydrochlorides
Differential thermal analysis
drying
sprayers

Keywords

  • β-Cyclodextrin
  • In vitro diffusion
  • Inclusion complexation
  • Lidocaine base
  • Rate of dissolution
  • Thermoanalytical investigations

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Preparation and investigation of mixtures containing lidocaine base and β-cyclodextrin. / Tatai, Anita; Aigner, Z.; Erös, I.; Kata, Mihály.

In: Journal of Inclusion Phenomena, Vol. 59, No. 1-2, 10.2007, p. 105-113.

Research output: Contribution to journalArticle

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