Preparation and investigation of mefenamic acid - polyethylene glycol - sucrose ester solid dispersions

Ibolya Fülöp, Árpád Gyéresi, Lóránd Kiss, Mária A. Deli, Mircea Dumitru Croitoru, Piroska Szabó-Révész, Zoltán Aigner

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8 Citations (Scopus)


Mefenamic acid (MA) is a widely used non-steroidal antiinflammatory (NSAID) drug. The adverse effects typical of NSAIDs are also present in the case of MA, partly due to its low water solubility. The aim of this study was to increase the water solubility of MA in order to influence its absorption and bioavailability. Solid dispersions of MA were prepared by the melting method using polyethylene glycol 6000 and different types (laurate, D-1216; palmitate, P-1670; stearate, S-1670) and amounts of sucrose esters as carriers. The X-ray diffraction results show that MA crystals were not present in the products. Dissolution tests carried out in artificial intestinal juice showed that the product containing 10 % D-1216 increased water solubility about 3 times. The apparent permeability coefficient of MA across human Caco-2 intestinal epithelial cell layers was high and, despite the difference in solubility, there was no further increase in drug penetration in the presence of the applied additives.

Original languageEnglish
Pages (from-to)453-462
Number of pages10
JournalActa Pharmaceutica
Issue number4
Publication statusPublished - Dec 1 2015



  • Caco-2 cells
  • PEG 6000
  • mefenamic acid
  • solid dispersion
  • sucrose esters

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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