Preparation and investigation of inclusion complexes containing nifluminic acid and cyclodextrins

Mihály Kata, Rita Ambrus, Z. Aigner

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Nifluminic acid (N) is a frequently used anti-inflammatory drug, but its poor aqueous solubility is a disadvantageous property. Inclusion complexation with cyclodextrin derivatives (CDs) affords a possibility to increase its solubility properties. For this purpose, different CDs were used, primarily hydroxypropyl-β-CD (HP-β-CD), to prepare products by powder mixing or kneading in four molecular ratios. The dissolution and in vitro membrane diffusion of the products were investigated. The wetting angles of pure N and HP-β-CD and of the products, and the n-octanol/water partition coefficients were determined. The interaction, leading to complex formation between the components of the products was examined by thermoanalytical methods.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalJournal of Inclusion Phenomena
Volume44
Issue number1-4
DOIs
Publication statusPublished - 2002

Fingerprint

cyclodextrins
Cyclodextrins
chemical derivatives
inclusions
Solubility
preparation
acids
Acids
products
octanol-water partition coefficients
1-Octanol
kneading
anti-inflammatory agents
contact angle
solubility
water solubility
Complexation
Powders
Wetting
powders

Keywords

  • Complexation
  • Dissolution
  • Hydroxypropyl-β-cyclodextrin
  • Nifluminic acid
  • Thermo-analytical investigation

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Preparation and investigation of inclusion complexes containing nifluminic acid and cyclodextrins. / Kata, Mihály; Ambrus, Rita; Aigner, Z.

In: Journal of Inclusion Phenomena, Vol. 44, No. 1-4, 2002, p. 123-126.

Research output: Contribution to journalArticle

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