Preparation and investigation of inclusion complexes containing gemfibrozil and DIMEB

Hassan Bin Hassan, Mihály Kata, István Erős, Zoltán Aigner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Gemfibrozil (GEM) is a xylyloxi-valeric acid derivative with an antilipaemic effect. This molecule has very poor water solubility, and the ability of different cyclodextrins (CDs) to form inclusion complexes was therefore tested. Primarily heptakis-2,6-di-O-methyl-β-cyclodextrin (DIMEB) was found to increase the solubility. The preparation of the complex in solid form for characterization was successful by means of physical mixing, kneading, spray-drying and ultrasonic treatment. The dissolution and in vitro membrane diffusion of the products were investigated. The n-octanol/water partition coefficients were determined for pure GEM and the DIMEB inclusion product, and the interactions leading to complex formation between the components of the products were examined by thermoanalytical methods and FTIR spectrophotometric analysis.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJournal of Inclusion Phenomena
Volume50
Issue number3-4
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Dissolution
  • FTIR
  • Gemfibrozil
  • Heptakis-2,6-di-O-methyl-β-cyclodextrin
  • Inclusion complexes
  • Membrane diffusion
  • Thermoanalytical investigations

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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