Gemfibrozil és dimetil-β-ciklodextrin termékek és szilárd gyógyszerformák eloállítása és vizsgálata

Translated title of the contribution: Preparation and investigation of Gemfibrozil + dimethyl-β-cyclodextrin products and solid dosage forms

Hassan Bin Hassan, Z. Aigner, Péter Kása, K. Pintye-Hódi, I. Erös

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Gemfibrozil is a lipid-regulating active substance. Dimethyl-β- cyclodextrin products were prepared from this sparingly soluble pharmacon by means of methods such as physical mixing, kneading, spray drying and ultrasonication. Solid dosage forms (hydroxypropylmethyl cellulose /HPMC/ capsules and tablets) were prepared from the selected products on the basis of their dissolution profile and the in vitro membrane diffusion results. This publication details the results of electronmicroscopic morphological studies, particle size analysis and wetting contact angle determinations, and also the preparation and examination of the resulting solid dosage forms.

Original languageHungarian
Pages (from-to)125-132
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume75
Issue number3
Publication statusPublished - 2005

Fingerprint

Gemfibrozil
Dosage Forms
Cyclodextrins
Particle Size
Cellulose
Tablets
Capsules
Lipids
Membranes
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Gemfibrozil és dimetil-β-ciklodextrin termékek és szilárd gyógyszerformák eloállítása és vizsgálata. / Hassan, Hassan Bin; Aigner, Z.; Kása, Péter; Pintye-Hódi, K.; Erös, I.

In: Acta Pharmaceutica Hungarica, Vol. 75, No. 3, 2005, p. 125-132.

Research output: Contribution to journalArticle

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