Introduction: Polymeric microparticles have an increasing importance as drug delivery systems in the field of medicine because of their controlled release properties. Polymeric microparticles can be applied intranasally for the delivery of drugs to reach the systemic circulation or directly the brain tissues. Aims: The aim of our work was to prepare and compare a synthetic polymer based microparticles by spray drying process, soluble at the pH of nasal mucosa. Methods: Empty and meloxicam (MEL-containing microparticles were produced, using the aqueous dispersion of an anionic copolymer based on methacrylic acid and ethyl acrylate with 30% dry substance. The initial liquid samples contained the MEL in dissolved and suspended form. After spray drying, the solid samples were investigated by structural and morphological analysis (DSC, XRPD, SEM), furthermore the in vitro dissolution test of products were carried out and compared with each other. Results: It was found that microcomposites with monodisperse particle size distribution were prepared, which contained the drug in molecularly dispersed or amorphous form. In vitro investigation of delivery system containing MEL in a molecularly form exhibited 70% of dissolved amount of drug in first 15 min at pH 5.6. Conclusion: Methacrylate copolymer based microcomposites may ensure the controlled release of non-steroidal anti-inflam- matory drugs because the starting rapid dissolution (15 min) is followed by slow rate release for 60 min using intranasal administration for pain management.
|Translated title of the contribution||Preparation and comparison of methacrylate copolymer-based microparticles for intranasal application|
|Number of pages||7|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Jan 1 2018|
ASJC Scopus subject areas
- Pharmaceutical Science