Metakrilat-kopolimer alapu mikroreszecskek eloallitasa es osszehasonlito vizsgalata intranazalis gyogyszerbevitel celjabol

Translated title of the contribution: Preparation and comparison of methacrylate copolymer-based microparticles for intranasal application

Bartos Csilla, Ambrus Rita, Bartos Csaba, P. Szabó-Révész

Research output: Contribution to journalArticle

Abstract

Introduction: Polymeric microparticles have an increasing importance as drug delivery systems in the field of medicine because of their controlled release properties. Polymeric microparticles can be applied intranasally for the delivery of drugs to reach the systemic circulation or directly the brain tissues. Aims: The aim of our work was to prepare and compare a synthetic polymer based microparticles by spray drying process, soluble at the pH of nasal mucosa. Methods: Empty and meloxicam (MEL-containing microparticles were produced, using the aqueous dispersion of an anionic copolymer based on methacrylic acid and ethyl acrylate with 30% dry substance. The initial liquid samples contained the MEL in dissolved and suspended form. After spray drying, the solid samples were investigated by structural and morphological analysis (DSC, XRPD, SEM), furthermore the in vitro dissolution test of products were carried out and compared with each other. Results: It was found that microcomposites with monodisperse particle size distribution were prepared, which contained the drug in molecularly dispersed or amorphous form. In vitro investigation of delivery system containing MEL in a molecularly form exhibited 70% of dissolved amount of drug in first 15 min at pH 5.6. Conclusion: Methacrylate copolymer based microcomposites may ensure the controlled release of non-steroidal anti-inflam- matory drugs because the starting rapid dissolution (15 min) is followed by slow rate release for 60 min using intranasal administration for pain management.

Original languageHungarian
Pages (from-to)237-243
Number of pages7
JournalActa pharmaceutica Hungarica
Volume88
Issue number4
Publication statusPublished - Jan 1 2018

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Methacrylates
meloxicam
Pharmaceutical Preparations
Intranasal Administration
Nasal Mucosa
Pain Management
Drug Delivery Systems
Particle Size
Polymers
Anti-Inflammatory Agents
Medicine
Brain
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Metakrilat-kopolimer alapu mikroreszecskek eloallitasa es osszehasonlito vizsgalata intranazalis gyogyszerbevitel celjabol. / Csilla, Bartos; Rita, Ambrus; Csaba, Bartos; Szabó-Révész, P.

In: Acta pharmaceutica Hungarica, Vol. 88, No. 4, 01.01.2018, p. 237-243.

Research output: Contribution to journalArticle

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