Preparation and characterization of nanofibrous sheets for enhanced oral dissolution of nebivolol hydrochloride

Emese Sipos, Zoltán István Szabó, Emőke Rédai, Péter Szabó, István Sebe, R. Zelkó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nebivolol-loaded electrospun nanofibrous sheets were prepared for the dissolution enhancement of the active with the aim of improving its oral bioavailability. Physicochemical characterization of nanofibers including differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy and positron annihilation lifetime spectroscopy were carried out in order to track the physicochemical changes related to the electrospinning process. The obtained results unanimously indicated the amorphous transition of nebivolol as a result of electrospinning, furthermore supramolecular ordering of chains of polyvinyl alcohol matrix could be revealed by positron annihilation lifetime spectroscopy. The crystalline-amorphous conversion of the active, along with the increased specific surface area of the nanofibers enabled rapid and complete dissolution. More than twice amount of active released from the fibrous sheets than from the commercial tablets. In contrast to the control tablets, the dissolution was complete and was not influenced by the pH of the applied media.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume129
DOIs
Publication statusPublished - Sep 10 2016

Fingerprint

Nebivolol
Nanofibers
Tablets
Spectrum Analysis
Dissolution
Positron annihilation
Electrospinning
Electrons
Polyvinyl Alcohol
Differential Scanning Calorimetry
Fourier Transform Infrared Spectroscopy
Spectroscopy
Biological Availability
Specific surface area
Differential scanning calorimetry
Crystalline materials

Keywords

  • Differential scanning calorimetry (DSC)
  • Dissolution enhancement
  • Electrospinning
  • Nanofibers
  • Nebivolol hydrochloride
  • Positron annihilation lifetime spectroscopy (PALS)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

Preparation and characterization of nanofibrous sheets for enhanced oral dissolution of nebivolol hydrochloride. / Sipos, Emese; Szabó, Zoltán István; Rédai, Emőke; Szabó, Péter; Sebe, István; Zelkó, R.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 129, 10.09.2016, p. 224-228.

Research output: Contribution to journalArticle

Sipos, Emese ; Szabó, Zoltán István ; Rédai, Emőke ; Szabó, Péter ; Sebe, István ; Zelkó, R. / Preparation and characterization of nanofibrous sheets for enhanced oral dissolution of nebivolol hydrochloride. In: Journal of Pharmaceutical and Biomedical Analysis. 2016 ; Vol. 129. pp. 224-228.
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AU - Szabó, Zoltán István

AU - Rédai, Emőke

AU - Szabó, Péter

AU - Sebe, István

AU - Zelkó, R.

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