Preparation and characterization of biocompatible electrospun nanofiber scaffolds

Edit Hirsch, Márió Nacsa, Ferenc Ender, M. Mohai, Zsombor K. Nagy, G. Marosi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nanoscale fibers were prepared for the fabrication of scaffolds by using a strong electrostatic field on the polymer solution. Electrospinning is widely applied for production of drug delivery, tissue engineering, and regenerative medicine systems as well as biosensors and enzyme immobilization. Nanofibers, thanks to their high surface area to volume ratio, can also mimic the extracellular matrix, thus it has been recognized as a suitable technique for the fast fabrication of scaffolds. This article demonstrates the fabrication of several nanofibrous scaffolds from biopolymers such as polycaprolactone, poly(lactic acid), poly(lactide-co-glycolide), poly(lactide-co-caprolactone) and poly(hydroxybutyrate-co-hydroxy valerate). The characterization and comparison of the scaffolds were achieved based on the morphology and surface characteristic of the nanofibers. The samples showed hydrophobic characteristic, thus a plasma surface treatment was applied successfully to increase hydrophilicity and the effect of the treatment was evaluated based on the wettability and the change in elemental composition of the surface based on X-ray photoelectron spectroscopy.

Original languageEnglish
Pages (from-to)510-518
Number of pages9
JournalPeriodica Polytechnica Chemical Engineering
Volume62
Issue number4
DOIs
Publication statusPublished - Nov 20 2018

Fingerprint

Nanofibers
Scaffolds
Fabrication
Hydroxybutyrates
Enzyme immobilization
Valerates
Polyglactin 910
Polycaprolactone
Biopolymers
Hydrophilicity
Electrospinning
Lactic acid
Polymer solutions
Drug delivery
Tissue engineering
Biosensors
Wetting
Surface treatment
X ray photoelectron spectroscopy
Electric fields

Keywords

  • Electrospinning
  • Nanomaterials
  • Plasma treatment
  • Scaffolds

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Preparation and characterization of biocompatible electrospun nanofiber scaffolds. / Hirsch, Edit; Nacsa, Márió; Ender, Ferenc; Mohai, M.; Nagy, Zsombor K.; Marosi, G.

In: Periodica Polytechnica Chemical Engineering, Vol. 62, No. 4, 20.11.2018, p. 510-518.

Research output: Contribution to journalArticle

Hirsch, Edit ; Nacsa, Márió ; Ender, Ferenc ; Mohai, M. ; Nagy, Zsombor K. ; Marosi, G. / Preparation and characterization of biocompatible electrospun nanofiber scaffolds. In: Periodica Polytechnica Chemical Engineering. 2018 ; Vol. 62, No. 4. pp. 510-518.
@article{8efb752a027842fc830a77f512acd529,
title = "Preparation and characterization of biocompatible electrospun nanofiber scaffolds",
abstract = "Nanoscale fibers were prepared for the fabrication of scaffolds by using a strong electrostatic field on the polymer solution. Electrospinning is widely applied for production of drug delivery, tissue engineering, and regenerative medicine systems as well as biosensors and enzyme immobilization. Nanofibers, thanks to their high surface area to volume ratio, can also mimic the extracellular matrix, thus it has been recognized as a suitable technique for the fast fabrication of scaffolds. This article demonstrates the fabrication of several nanofibrous scaffolds from biopolymers such as polycaprolactone, poly(lactic acid), poly(lactide-co-glycolide), poly(lactide-co-caprolactone) and poly(hydroxybutyrate-co-hydroxy valerate). The characterization and comparison of the scaffolds were achieved based on the morphology and surface characteristic of the nanofibers. The samples showed hydrophobic characteristic, thus a plasma surface treatment was applied successfully to increase hydrophilicity and the effect of the treatment was evaluated based on the wettability and the change in elemental composition of the surface based on X-ray photoelectron spectroscopy.",
keywords = "Electrospinning, Nanomaterials, Plasma treatment, Scaffolds",
author = "Edit Hirsch and M{\'a}ri{\'o} Nacsa and Ferenc Ender and M. Mohai and Nagy, {Zsombor K.} and G. Marosi",
year = "2018",
month = "11",
day = "20",
doi = "10.3311/PPch.12854",
language = "English",
volume = "62",
pages = "510--518",
journal = "Periodica Polytechnica: Chemical Engineering",
issn = "0324-5853",
publisher = "Budapest University of Technology and Economics",
number = "4",

}

TY - JOUR

T1 - Preparation and characterization of biocompatible electrospun nanofiber scaffolds

AU - Hirsch, Edit

AU - Nacsa, Márió

AU - Ender, Ferenc

AU - Mohai, M.

AU - Nagy, Zsombor K.

AU - Marosi, G.

PY - 2018/11/20

Y1 - 2018/11/20

N2 - Nanoscale fibers were prepared for the fabrication of scaffolds by using a strong electrostatic field on the polymer solution. Electrospinning is widely applied for production of drug delivery, tissue engineering, and regenerative medicine systems as well as biosensors and enzyme immobilization. Nanofibers, thanks to their high surface area to volume ratio, can also mimic the extracellular matrix, thus it has been recognized as a suitable technique for the fast fabrication of scaffolds. This article demonstrates the fabrication of several nanofibrous scaffolds from biopolymers such as polycaprolactone, poly(lactic acid), poly(lactide-co-glycolide), poly(lactide-co-caprolactone) and poly(hydroxybutyrate-co-hydroxy valerate). The characterization and comparison of the scaffolds were achieved based on the morphology and surface characteristic of the nanofibers. The samples showed hydrophobic characteristic, thus a plasma surface treatment was applied successfully to increase hydrophilicity and the effect of the treatment was evaluated based on the wettability and the change in elemental composition of the surface based on X-ray photoelectron spectroscopy.

AB - Nanoscale fibers were prepared for the fabrication of scaffolds by using a strong electrostatic field on the polymer solution. Electrospinning is widely applied for production of drug delivery, tissue engineering, and regenerative medicine systems as well as biosensors and enzyme immobilization. Nanofibers, thanks to their high surface area to volume ratio, can also mimic the extracellular matrix, thus it has been recognized as a suitable technique for the fast fabrication of scaffolds. This article demonstrates the fabrication of several nanofibrous scaffolds from biopolymers such as polycaprolactone, poly(lactic acid), poly(lactide-co-glycolide), poly(lactide-co-caprolactone) and poly(hydroxybutyrate-co-hydroxy valerate). The characterization and comparison of the scaffolds were achieved based on the morphology and surface characteristic of the nanofibers. The samples showed hydrophobic characteristic, thus a plasma surface treatment was applied successfully to increase hydrophilicity and the effect of the treatment was evaluated based on the wettability and the change in elemental composition of the surface based on X-ray photoelectron spectroscopy.

KW - Electrospinning

KW - Nanomaterials

KW - Plasma treatment

KW - Scaffolds

UR - http://www.scopus.com/inward/record.url?scp=85058775001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058775001&partnerID=8YFLogxK

U2 - 10.3311/PPch.12854

DO - 10.3311/PPch.12854

M3 - Article

AN - SCOPUS:85058775001

VL - 62

SP - 510

EP - 518

JO - Periodica Polytechnica: Chemical Engineering

JF - Periodica Polytechnica: Chemical Engineering

SN - 0324-5853

IS - 4

ER -