Prenatal exposure to morphine alters brain μ opioid receptor characteristics in rats

A. Rimanóczy, Ilona Vathy

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Prenatal morphine exposure alters neither the binding capacity nor the affinity of ligand binding to μ opioid receptors of adult male brains. However, males have significantly higherBmax in the hypothalamus than ovariectomized females. In females, prenatal exposure to morphine reduces theBmax of μ opioid receptors 25% in the hypothalamus and preoptic area. Estrogen treatment increases theBmax of μ opioid receptors in the striatum of all ovariectomized females but in the hypothalamus only of morphine-exposed females, thereby eliminating the sex difference observed in control animals.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalBrain Research
Volume690
Issue number2
DOIs
Publication statusPublished - Sep 4 1995

Fingerprint

Opioid Receptors
Morphine
Hypothalamus
Brain
Preoptic Area
Sex Characteristics
Estrogens
Ligands

Keywords

  • Hypothalamus
  • Prenatal morphine
  • Sex dimorphism
  • μ Opioid receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Prenatal exposure to morphine alters brain μ opioid receptor characteristics in rats. / Rimanóczy, A.; Vathy, Ilona.

In: Brain Research, Vol. 690, No. 2, 04.09.1995, p. 245-248.

Research output: Contribution to journalArticle

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