Prenatal dietary fumonisin B 1 exposure may modify learning processes in rat offspring

Ilona Banczerowski-Pelyhe, Péter Banczerowski, Petra Varró, Ildikó Világi

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Abstract

Changes of long term potentiation (LTP) as an elementary learning model in the first generation offspring of fumonisin B 1 (FB 1) treated pregnant rats were studied. Prenatal exposition to FB 1 caused marked and significant alterations and anomalies in in vitro brain slice bioelectric activity. This is the first study to use in vitro rat cortex slices as biosensors monitoring LTP changes in offspring after FB 1 exposition of pregnant rats, and providing evidence for brain functional bioelectric anomalies of neurodevelopmental origin caused by mycotoxin FB 1.

Original languageEnglish
Pages (from-to)1947-1950
Number of pages4
JournalCereal Research Communications
Volume36
Issue numberSUPPL. 5
DOIs
Publication statusPublished - Dec 1 2008

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Keywords

  • Developmental risks
  • Developmental toxicity
  • Fumonisin B
  • In vitro biotests
  • LTP
  • Rat cortex slice

ASJC Scopus subject areas

  • Physiology
  • Agronomy and Crop Science
  • Genetics

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