Premature centromere division: A possible manifestation of chromosome instability

K. Mehes, E. M. Buhler

Research output: Contribution to journalArticle

33 Citations (Scopus)


Retrospective analysis of 'routine' chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxiateleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalAmerican journal of medical genetics
Issue number1
Publication statusPublished - Mar 13 1995


ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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