Preliminary study of TIP47 as a possible new biomarker of cervical dysplasia and invasive carcinoma

A. Szigeti, Orsolya Minik, Eniko Hocsak, Eva Pozsgai, A. Boronkai, Robert Farkas, Andras Balint, Jozsef Bodis, B. Sümegi, S. Bellyei

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to find a possible clinical use of the tail-interacting protein of 47 kDa (TIP47) and further document its expression in smear cytology, different cervical dysplasias, invasive cervical cancer and metastasis. Patients and Methods: A new polyclonal anti-TIP47 antibody was developed and used on smears and histological cervix sections of sixty women with different cytological pathologies. Serum TIP47 level of patients with cervical intraepithelial neoplasia (CIN) or carcinoma in stage IIb, IIIa, and IIIb was monitored during treatment. Results: TIP47 was expressed weakly in the dysplasias, stronger in invasive tumors and in lymph node metastasis. In patients with cervical carcinoma, the serum TIP47 level was found to be elevated; it decreased after therapy and elevated again in relapse. Conclusion: According to our results, TIP47 could be a good clinical marker for the early detection in blood of the recurrence of cervical carcinoma.

Original languageEnglish
Pages (from-to)717-724
Number of pages8
JournalAnticancer Research
Volume29
Issue number2
Publication statusPublished - Feb 2009

Fingerprint

Uterine Cervical Dysplasia
Biomarkers
Carcinoma
Neoplasm Metastasis
Recurrence
Cervical Intraepithelial Neoplasia
Serum
Cervix Uteri
Uterine Cervical Neoplasms
Cell Biology
Perilipin-3
Lymph Nodes
Pathology
Antibodies
Therapeutics
Neoplasms

Keywords

  • Cervical cytology
  • Neoplasm metastasis
  • TIP47
  • Tumor marker
  • Uterine cervical neoplasm

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Preliminary study of TIP47 as a possible new biomarker of cervical dysplasia and invasive carcinoma. / Szigeti, A.; Minik, Orsolya; Hocsak, Eniko; Pozsgai, Eva; Boronkai, A.; Farkas, Robert; Balint, Andras; Bodis, Jozsef; Sümegi, B.; Bellyei, S.

In: Anticancer Research, Vol. 29, No. 2, 02.2009, p. 717-724.

Research output: Contribution to journalArticle

Szigeti, A. ; Minik, Orsolya ; Hocsak, Eniko ; Pozsgai, Eva ; Boronkai, A. ; Farkas, Robert ; Balint, Andras ; Bodis, Jozsef ; Sümegi, B. ; Bellyei, S. / Preliminary study of TIP47 as a possible new biomarker of cervical dysplasia and invasive carcinoma. In: Anticancer Research. 2009 ; Vol. 29, No. 2. pp. 717-724.
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AU - Boronkai, A.

AU - Farkas, Robert

AU - Balint, Andras

AU - Bodis, Jozsef

AU - Sümegi, B.

AU - Bellyei, S.

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