Preliminary study of different omeprazole-γ-CD co-grinded systems

M. J. Arias-Blanco, P. Muñoz, J. R. Moyano, J. M. Ginés, C. Novak

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this work, we illustrate the usefulness of co-grinding as a resourceful procedure for preparing OME-γ-CD inclusion complexes with faster and higher dissolution characteristics than the drug alone. Different modified Variants of the co-grinding processing method have been checked, and DRX, SEM and dissolution rate studies have been employed to characterize the final products. The main conclusion arising from the former studies has been the obtention of a new solid phase, the OME-γ-CD inclusion compound, after buffer-wetted co-grinding of both components during 4 h. Such complex presented a 170-folded DE15 respecting the pure OME.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume143
Issue number1
DOIs
Publication statusPublished - Oct 25 1996

Keywords

  • Co-grinding
  • Dissolution rate
  • Omeprazole
  • SEM
  • XRD
  • γ-Cyclodextrin

ASJC Scopus subject areas

  • Pharmaceutical Science

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