Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy

Preparation, size determination, in-vivo distribution, effects and dosimetry studies

Domokos Máthe, Pradip R. Chaudhari, Lajos Balogh, András Polyák, Réka Király, Gábor Andócs, Edina Perge, Róbert Glávits, Gyõzõ A. Jánoki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Generator-produced beta-emitting radionuclides such as 188Re are gaining in importance for radiosynoviorthesis because of their availability on a regular basis. Material and Methods: We prepared a 188Re-tin colloid in a reaction carried out either at 100°C or at room temperature (RT). The size of the colloid particles was measured with a laser light-scattering method, and their biodistribution, dosimetric aspects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed. Blood samples were collected post injection for estimation of the blood residence time. We also injected 2 intact rabbits in the same manner with 188Re perrhenate solution in order to observe its effects and distribution in the body. All the treated rabbit knees were subjected to histopathology. Results: The colloid particle size distribution was different after preparation at the different reaction temperatures, with a more suitable mean of 4.53 μm in the RT preparation. The dose delivered to the synovial surface was between 3.51 and 4.21 Gy and that to the bone surface was between 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the AIA knees 4 weeks after treatment, but not in the control group. Conclusions: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. It requires modifications in the preparation protocol so as to increase the labeling efficiency in correlation with an appropriate particle size.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalNuclear Medicine Review
Volume5
Issue number2
Publication statusPublished - 2002

Fingerprint

Tin
Colloids
Particle Size
Radiation
Rabbits
Arthritis
Antigens
Temperature
Knee
Therapeutic Uses
Knee Joint
Radioisotopes
Connective Tissue
Lasers
Light
Bone and Bones
Control Groups
Injections
(188)Rhenium tin-colloid
Therapeutics

Keywords

  • Antigen-induced arthritis
  • Dosimetry
  • Radiocolloid
  • Radiopharmaceutical
  • Radiosynovectomy
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy : Preparation, size determination, in-vivo distribution, effects and dosimetry studies. / Máthe, Domokos; Chaudhari, Pradip R.; Balogh, Lajos; Polyák, András; Király, Réka; Andócs, Gábor; Perge, Edina; Glávits, Róbert; Jánoki, Gyõzõ A.

In: Nuclear Medicine Review, Vol. 5, No. 2, 2002, p. 99-104.

Research output: Contribution to journalArticle

Máthe, D, Chaudhari, PR, Balogh, L, Polyák, A, Király, R, Andócs, G, Perge, E, Glávits, R & Jánoki, GA 2002, 'Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy: Preparation, size determination, in-vivo distribution, effects and dosimetry studies', Nuclear Medicine Review, vol. 5, no. 2, pp. 99-104.
Máthe, Domokos ; Chaudhari, Pradip R. ; Balogh, Lajos ; Polyák, András ; Király, Réka ; Andócs, Gábor ; Perge, Edina ; Glávits, Róbert ; Jánoki, Gyõzõ A. / Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy : Preparation, size determination, in-vivo distribution, effects and dosimetry studies. In: Nuclear Medicine Review. 2002 ; Vol. 5, No. 2. pp. 99-104.
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abstract = "Background: Generator-produced beta-emitting radionuclides such as 188Re are gaining in importance for radiosynoviorthesis because of their availability on a regular basis. Material and Methods: We prepared a 188Re-tin colloid in a reaction carried out either at 100°C or at room temperature (RT). The size of the colloid particles was measured with a laser light-scattering method, and their biodistribution, dosimetric aspects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed. Blood samples were collected post injection for estimation of the blood residence time. We also injected 2 intact rabbits in the same manner with 188Re perrhenate solution in order to observe its effects and distribution in the body. All the treated rabbit knees were subjected to histopathology. Results: The colloid particle size distribution was different after preparation at the different reaction temperatures, with a more suitable mean of 4.53 μm in the RT preparation. The dose delivered to the synovial surface was between 3.51 and 4.21 Gy and that to the bone surface was between 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the AIA knees 4 weeks after treatment, but not in the control group. Conclusions: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. It requires modifications in the preparation protocol so as to increase the labeling efficiency in correlation with an appropriate particle size.",
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T2 - Preparation, size determination, in-vivo distribution, effects and dosimetry studies

AU - Máthe, Domokos

AU - Chaudhari, Pradip R.

AU - Balogh, Lajos

AU - Polyák, András

AU - Király, Réka

AU - Andócs, Gábor

AU - Perge, Edina

AU - Glávits, Róbert

AU - Jánoki, Gyõzõ A.

PY - 2002

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N2 - Background: Generator-produced beta-emitting radionuclides such as 188Re are gaining in importance for radiosynoviorthesis because of their availability on a regular basis. Material and Methods: We prepared a 188Re-tin colloid in a reaction carried out either at 100°C or at room temperature (RT). The size of the colloid particles was measured with a laser light-scattering method, and their biodistribution, dosimetric aspects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed. Blood samples were collected post injection for estimation of the blood residence time. We also injected 2 intact rabbits in the same manner with 188Re perrhenate solution in order to observe its effects and distribution in the body. All the treated rabbit knees were subjected to histopathology. Results: The colloid particle size distribution was different after preparation at the different reaction temperatures, with a more suitable mean of 4.53 μm in the RT preparation. The dose delivered to the synovial surface was between 3.51 and 4.21 Gy and that to the bone surface was between 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the AIA knees 4 weeks after treatment, but not in the control group. Conclusions: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. It requires modifications in the preparation protocol so as to increase the labeling efficiency in correlation with an appropriate particle size.

AB - Background: Generator-produced beta-emitting radionuclides such as 188Re are gaining in importance for radiosynoviorthesis because of their availability on a regular basis. Material and Methods: We prepared a 188Re-tin colloid in a reaction carried out either at 100°C or at room temperature (RT). The size of the colloid particles was measured with a laser light-scattering method, and their biodistribution, dosimetric aspects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed. Blood samples were collected post injection for estimation of the blood residence time. We also injected 2 intact rabbits in the same manner with 188Re perrhenate solution in order to observe its effects and distribution in the body. All the treated rabbit knees were subjected to histopathology. Results: The colloid particle size distribution was different after preparation at the different reaction temperatures, with a more suitable mean of 4.53 μm in the RT preparation. The dose delivered to the synovial surface was between 3.51 and 4.21 Gy and that to the bone surface was between 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the AIA knees 4 weeks after treatment, but not in the control group. Conclusions: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. It requires modifications in the preparation protocol so as to increase the labeling efficiency in correlation with an appropriate particle size.

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